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Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
Novel Functions of ErbB4 and NRG-1 in Development and Cancer
(Annales Universitatis Turkuensis D 1060Turun yliopisto, 2013-03-22)
Cells communicate, or signal, with each other constantly to ensure proper functioning of tissues and organs. Cell signaling is often performed by interplay of receptors and ligands that bind these receptors. ErbB receptors ...
Reactive oxygen species in inflammation
(Annales Universitatis Turkuensis D 1063Turun yliopisto, 2013-04-26)
Chronic inflammation is the underlying cause of many common disabling conditions such as rheumatoid arthritis (RA), multiple sclerosis, coeliac disease, type I diabetes and coronary artery disease. NOX2 complex derived ...
Chromatoid body mediated RNA regulation in mouse male germline
(Annales Universitatis Turkuensis D 1099Turun yliopisto, 2013-12-20)
Male germ cell differentiation, spermatogenesis is an exceptional developmental process that produces a massive amount of genetically unique spermatozoa. The complexity of this process along with the technical limitations ...
Differentiation of Metabolically Distinct Areas within Head and Neck Region using Dynamic 18F-FDG Positron Emission Tomography Imaging
(Turun yliopisto, 2014-01-28)
Positron Emission Tomography (PET) using <sup>18</sup>F-FDG is playing a vital role in the diagnosis and treatment planning of cancer. However, the most widely used radiotracer, <sup>18</sup>F-FDG, is not specific for ...
System-level characterization of Th2 cell development and immune cell responses to ZnO and TiO2 nanoparticles
(Annales Universitatis Turkuensis D 1064Turun yliopisto, 2013-04-26)
Asthma and allergy are common diseases and their prevalence is increasing. One of the hypotheses that explains this trend is exposure to inhalable chemicals such as traffi c-related air pollution. Epidemiological research ...
Markers of Bone Turnover In Preclinical Development of Drugs for Skeletal Diseases
(Annales Universitatis Turkuensis D 1092Turun yliopisto, 2013-11-15)
Skeletal tissue is constantly remodeled in a process where osteoclasts resorb old bone and osteoblasts form new bone. Balance in bone remodeling is related to age, gender and genetic factors, but also many skeletal diseases, ...
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
(Turun yliopisto, 2022-01-21)
The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...
Disruption of Clever-1 for Novel Anticancer Immunotherapy
(Turun yliopisto, 2016-11-22)
The progression of cancer is dependent on the quality of the immune response elicited by the tumour. Typically, proinflammatory immune responses restrain and anti-inflammatory immune responses promote the progression of ...
Two-photon excitation fluorometry in detection of infectious diseases
(Annales Universitatis Turkuensis AI 384Turun yliopisto, 2008-11-21)
Because of the heavily overlapping symptoms, pathogen-specific diagnosis and treatment of infectious diseases is difficult based on clinical symptoms alone. Therefore, patients are often treated empirically. More efficient ...