Hae
Aineistot 11-15 / 15
ADMET and adverse effects predictive modeling based on FDA-approved drugs Data
(Turun yliopisto, 2017-01-31)
Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and adverse effects determine the success of each drug. These factors play an important role in the late-stage failure of drug candidates and ...
Annotation of Gyrodactylus salaris transcriptome
(Turun yliopisto, 2016-06-15)
Relationship between organisms within an ecosystem is one of the main focuses in the study of ecology and evolution. For instance, host-parasite interactions have long been under close interest of ecology, evolutionary ...
Molecular modeling studies of Escherichia coli MurA towards novel Mur enzyme inhibitors against resistant bacterial strains
(Turun yliopisto, 2016-12-21)
Currently more and more antibiotics are put into clinical use; meanwhile bacteria also develop diverse antibiotic resistance. MurA, a key enzyme on cell wall precursor biosynthesis pathway, was effectively inhibited by a ...
De novo transcriptome assembly and annotation of the isopod Idotea balthica
(Turun yliopisto, 2016-05-24)
The Baltic Sea is a unique environment that contains unique genetic populations. In order to study these populations on a genetic level basic molecular research is needed. The aim of this thesis was to provide a basic ...
In silico metabolic modelling of Saccharomyces cerevisiae for the overproduction of succinate using OptKnock and OptGene
(Turun yliopisto, 2016-06-08)
Succinate is a naturally occurring metabolite in organism’s cell and is industrially important chemical with various applications in food and pharmaceutical industry. It is also widely used to produce bio-degradable plastics, ...