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Aineistot 11-20 / 151
MicroRNA-107 Regulates Adiponectin Expression and Human Adipocyte Differentiation
(2019-05-14)
Adiponectin (AdipoQ) is a major adipokine with insulin-sensitizing and anti-inflammatory effects. AdipoQ expression is downregulated in obesity, insulin resistance and type 2 diabetes. In this study, we investigated the ...
The role of plasmacytoid dendritic cells in mucosal immune response during Citrobacter rodentium -infection
(Turun yliopisto, 2018-07-02)
The Antigen Processing Pathway in B Cells Utilizes Peripheral Endocytic Recycling Compartments
(2019-10-24)
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as antigen presenting cells: they internalize protein antigens and process them into peptides for presentation on Major ...
Towards targeting SAMHD1 to improve cytarabine therapy for hematological malignancies
(2018-09-26)
Acute myeloid leukemia (AML) is a hematological cancer where myeloid stem cells are transformed into malignant cells, filling and replacing the cells in a healthy bone marrow. Cytarabine is a nucleoside analog used in ...
JNK regulation of nerve cell calcium : a possible mechanism in psychiatric disease
(2019-03-27)
Psychiatric disorders are a big problem in the modern world. The symptoms of these diseases vary, but common for all of them is that they are overpowering, consistent, and hamper daily life. Even though many treatments are ...
Significance of HSD17B1 in breast and ovarian cancer - validation of novel HSD17B1 antibodies
(Turun yliopisto, 2017-10-04)
Interaction of silica with human immune cells
(2018-12-18)
Aim of this study was to evaluate silica’s ability to promote inflammation. Amorphous silica could be used in sustained drug delivery systems, but it needs to be proven to be safe.
Neutrophils ability to phagocytose ...
Technical and Clinical Assessment of Custom HaloPlex Target Enrichment and High-Throughput Sequencing Assay In Foetal and Infant Forensic Pathology
(Turun yliopisto, 2017-09-27)
Channelopathies, cardiomyopathies and certain inborn errors of metabolism cause unexpected death during gestation and infancy. The fatality can occur suddenly or after a rapidly progressive disease. Frequently, the diseases ...
In Vitro α-synuclein aggregation assay for studying induced cellular stress, drug targets and compounds
(2019-11-28)
Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...
Treatment of herpes simplex virus infection using antiviral siRNA swarms with 2’-fluoro-modifications
(2020-04-28)
Herpes simplex virus 1 (HSV-1) is a very common pathogen. Besides mostly harmless oral lesions, HSV-1 causes severe diseases such as neonatal herpes, herpes encephalitis and herpes keratitis, the primary cause of infectious ...