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The influence of maternal prenatal stress on the infant's gut microbiota development
(2020-08-27)
Early life stress is known to have adverse, long lasting consequences on an infant’s behavioral, emotional and cognitive development, capable of persisting into adulthood. Early life stress initially manifests as maternal ...
Analysis of differential alternative splicing at the gene isoform and genomic levels using Cufflinks, Miso, and rMats – an example of ANO7 in prostate cancer
(2020-06-05)
The diagnosis and treatment of prostate cancer (PCa) are the most extensively researched fields in Urology. Studying gene expression profiling in PCa as well as in other types of cancer necessitates the investigation of ...
Introducing deep learning -based methods into the variant calling analysis pipeline
(2019-05-24)
Biological interpretation of the genetic variation enhances our understanding of normal and pathological phenotypes, and may lead to the development of new therapeutics.
However, it is heavily dependent on the genomic ...
The properties of the last universal common ancestor
(2019-04-11)
The last universal common ancestor is believed to be an organism from which all modern organisms on earth today are thought to be descended from. LUCA is thought to be the recent most ancestor to all present-day organisms ...
Comparison of de novo metagenomic assembly tools
(2019-05-24)
The field of metagenomics involves studying the composition and function of microbial communities via isolated DNA from a variety of environments like soil, water and the human gut. Since the current generation sequencing ...
Assessing Data Quality in Disease-Specific Patient Information Systems
(2020-05-19)
BCB Medical provides disease-specific patient information systems for collection of patient data, and information services for clinical research as well as for public and private hospitals. There are over 100 disease-specific ...
Power analysis for RNA sequencing and mass spectrometry-based proteomics data
(2019-02-12)
RNA-sequencing and mass spectrometry technologies have facilitated the differential expression discoveries in transcriptome and proteome studies. However, the determination of sample size to achieve adequate statistical ...
Comparison of five popular normalization methods using a spike-in proteomics data set
(Turun yliopisto, 2016-08-18)
Mass spectrometry (MS)-based proteomics has seen significant technical advances during the past two decades and mass spectrometry has become a central tool in many biosciences. Despite the popularity of MS-based methods, ...
Probing MST1 Kinase Sequence and Structure for Rational Drug Discovery (Targeting diabetes by blocking protein-protein interactions)
(Turun yliopisto, 2016-04-26)
Apoptotic beta cell death is an underlying cause majorly for type I and to a lesser extent for type II diabetes. Recently, MST1 kinase was identified as a key apoptotic agent in diabetic condition. In this study, I have ...
Development of pipeline for gut microbiome data analysis using R programming
(2022-01-31)
Microorganisms are present everywhere in the environment. They are present on and inside of all higher organisms and they can be harmful as well as useful for the host. Microorganisms play an important role in the evolution ...