Hae
Aineistot 11-20 / 92
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
Functional characterization of a humanized anti-Clever-1 antibody targeting monocytes and anti-inflammatory macrophages
(2018-11-29)
Targeting the immunosuppressive tumor microenvironment has gained interest in opening new avenues to fight against cancer growth. Macrophages are extremely potential candidates for targeted therapies due to their highly ...
Protein-encapsulated in mesoporous silica nanoparticles for the the treatment of bacterial biofilms
(2019-05-13)
80% of infections are estimated to be biofilm related, which are extremely resistant to anti-microbials. It remains an unmet need to develop medications to treat biofilms. Currently, there are evolving approaches that use ...
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(2020-05-11)
Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...
Cell signaling in breast cancer associated with neurofibromatosis type 1
(2020-04-30)
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...
Intracellular metabolism and transport of paclitaxel in ovarian cancer
(2020-04-30)
Although traditional chemotherapies are still the backbone of ovarian cancer treatment, interpatient variability in drug response and acquired resistance still present a major hurdle. The antimitotic agent, paclitaxel, is ...
Spatial Engineering of Human Breast Tissue Cultures by 3D Bioprinting
(2022-08-29)
Extracellular matrix (ECM) is an integral part of breast tissue microenvironment, and it plays important roles in mammary gland development and homeostasis as well as in breast cancer progression. However, the in vivo ...
The role of bacterial lipopolysaccharides and gut microbiota dysbiosis in type 1 diabetes
(2022-10-10)
The definitive etiology of type 1 diabetes (T1D) remains uncertain. However, various studies suggest that gut microbiota dysbiosis might contribute to the development of islet autoimmunity. This risk could be mediated by ...
Hippo pathway activity after a peripheral nerve injury
(2022-04-14)
Transcriptional mechanisms underlying chronic neuropathic pain are still unclear. However, novel studies have suggested that the Hippo pathway and especially its compartments YAP and TAZ have a role in the pathology of ...
In Vitro Characterization of Herpes Simplex Virus Type 1 Clinical Isolates with Respect to Their Potential as Gene Vectors
(2022-04-26)
Herpes simplex virus 1 (HSV-1) is a common human pathogen that can be found in approximately half of the population. Typically, it causes relatively mild symptoms such as cold sores, though HSV-1 can also enter a latent ...