Hae
Aineistot 11-16 / 16
Implementation of modern methods to identify DNA methylation marks for episodic memory impairment and Alzheimer’s disease
(Turun yliopisto, 2020-10-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...
Screening of novel therapeutic targets and risk alleles for cardiac disorders
(Turun yliopisto, 2020-11-27)
Ischemic heart disease is the leading cause of death globally, even though the prognosis of the disease has improved with advancing treatments. One particular phenomenon which could be treated more effectively is ...
Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases
(Turun yliopisto, 2021-09-10)
ABSTRACT
Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...
Wnt signaling in the regulation of bone and cartilage metabolism
(Turun yliopisto, 2021-10-22)
Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...
Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...
Mechanisms of receptor tyrosine kinase signaling diversity: a focus in cardiac growth
(Turun yliopisto, 2023-12-15)
To understand organism function and disease and to target perturbed processes for therapy, comprehensive knowledge of the underlying cell signaling networks is required. However, mapping the interplay of the vast number ...