Hae
Aineistot 11-20 / 20
Structural and Mechanistic Studies of Phosphoserine Aminotransferase
(Turun yliopisto, 2015-12-11)
Phosphoserine aminotrasferase (PSAT: EC 2.6.1.52) is a vitamin B6-dependent enzyme and a member of the subgroup IV in the aminotransferase superfamily. Here, X-ray crystallography was used to determine the structure of ...
Optimization and Applications of Large-Scale Biomedical Event Networks
(Turun yliopisto, 2016-06-01)
The overwhelming amount and unprecedented speed of publication in the biomedical domain make it difficult for life science researchers to acquire and maintain a broad view of the field and gather all information that would ...
Analysis of Alpha CA Genes in Early Vertebrates and ; High-Invertebrates
(Turun yliopisto, 2016-06-08)
Carbonic anhydrases are enzymes that are ubiquitously found in all organisms that are engaged in catalyzing the hydration of carbon dioxide to form bicarbonate and proton and vice versa. They are crucial in the process of ...
Implementation of Quantitative Reaction-based Model Refinement
(Turun yliopisto, 2015-10-13)
Building a computational model for complex biological systems is an iterative process. It starts from an abstraction of the process and then incorporates more details regarding the specific biochemical reactions which ...
Prediction of Phosphorylation Sites from Protein Sequences
(Turun yliopisto, 2016-06-15)
Phosphorylation is amongst the most crucial and well-studied post-translational modifications. It is involved in multiple cellular processes which makes phosphorylation prediction vital for understanding protein functions. ...
ADMET and adverse effects predictive modeling based on FDA-approved drugs Data
(Turun yliopisto, 2017-01-31)
Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and adverse effects determine the success of each drug. These factors play an important role in the late-stage failure of drug candidates and ...
Annotation of Gyrodactylus salaris transcriptome
(Turun yliopisto, 2016-06-15)
Relationship between organisms within an ecosystem is one of the main focuses in the study of ecology and evolution. For instance, host-parasite interactions have long been under close interest of ecology, evolutionary ...
Molecular modeling studies of Escherichia coli MurA towards novel Mur enzyme inhibitors against resistant bacterial strains
(Turun yliopisto, 2016-12-21)
Currently more and more antibiotics are put into clinical use; meanwhile bacteria also develop diverse antibiotic resistance. MurA, a key enzyme on cell wall precursor biosynthesis pathway, was effectively inhibited by a ...
De novo transcriptome assembly and annotation of the isopod Idotea balthica
(Turun yliopisto, 2016-05-24)
The Baltic Sea is a unique environment that contains unique genetic populations. In order to study these populations on a genetic level basic molecular research is needed. The aim of this thesis was to provide a basic ...
In silico metabolic modelling of Saccharomyces cerevisiae for the overproduction of succinate using OptKnock and OptGene
(Turun yliopisto, 2016-06-08)
Succinate is a naturally occurring metabolite in organism’s cell and is industrially important chemical with various applications in food and pharmaceutical industry. It is also widely used to produce bio-degradable plastics, ...