Aineistot 11-16 / 16
The effect of melanocortin-1 receptor deficiency on cholesterol transporter genes in atherosclerotic ApoE knockout mouse model
(Turun yliopisto, 2017-07-20)
The melanocortin system comprises of melanocortin peptides; α-, β- and γ- melanocortin stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) derived from the proteolytic degradation ...
Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
Fadolmidine – an alpha2-adrenoceptor agonist for spinal analgesia : analgesic effect and safety in preclinical in vivo models
(Turun yliopisto, 2021-01-29)
Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ...
Cavity-based negative images in molecular docking
(Turun yliopisto, 2021-10-01)
In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ...
Patient recruitment, feasibility evaluations and use of electronic health records in clinical trials - A Nordic approach
(Turun yliopisto, 2021-11-19)
Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ...
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
(Turun yliopisto, 2022-01-21)
The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...