Hae
Aineistot 221-230 / 578
Diet, microbes and gut immune responses in the pathogenesis of experimental type 1 diabetes
(Annales Universitatis Turkuensis D 1242Turun yliopisto, 2016-09-09)
Type 1diabetes (T1D) is an autoimmune disease, which is influenced by a variety of environmental factors including diet and microbes. These factors affect the homeostasis and the immune system of ...
Integrins on the move
(Annales Universitatis Turkuensis D 1080Turun yliopisto, 2013-06-14)
Cancer is a leading cause of death worldwide accounting for 13% of all deaths
in 2005. The spread of cancer and formation of metastases is the major cause
of mortality among cancer patients.
The spread of cancer is ...
Life without Phd? – Phd Oxygen Sensor Proteins in Hypoxic Carcinoma Cell Survival
(Turun yliopisto, 2016-05-20)
The microenvironment within the tumor plays a central role in cellular signaling. Rapidly proliferating cancer cells need building blocks for structures as well as nutrients and oxygen for energy production. In normal ...
Nopea Sertolin solujen eristäminen aikuisista hiiristä lektiinin avulla
(Turun yliopisto, 2017-04-04)
The Role of an Oncoprotein CIP2A in Breast Cancer
(Annales Universitatis Turkuensis D 1078Turun yliopisto, 2013-06-14)
Cancerous inhibitor of PP2A (CIP2A) is an oncoprotein expressed in several
human cancer types. Previously, CIP2A has been shown to promote
proliferation of cancer cells. Mechanistically, CIP2A is known to inhibit ...
Treatment of herpes simplex virus infection using antiviral siRNA swarms with 2’-fluoro-modifications
(2020-04-28)
Herpes simplex virus 1 (HSV-1) is a very common pathogen. Besides mostly harmless oral lesions, HSV-1 causes severe diseases such as neonatal herpes, herpes encephalitis and herpes keratitis, the primary cause of infectious ...
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
Role of fibroblast growth factors and their receptors in prostate cancer
(Annales Universitatis Turkuensis D 1234Turun yliopisto, 2016-06-17)
Prostate cancer (PCa) is the most common non-cutaneous malignant disease among males in the developed countries. Radical prostatectomy (RP) is an effective therapy for most PCa patients with localized or locally invaded ...
Functional characterization of a humanized anti-Clever-1 antibody targeting monocytes and anti-inflammatory macrophages
(2018-11-29)
Targeting the immunosuppressive tumor microenvironment has gained interest in opening new avenues to fight against cancer growth. Macrophages are extremely potential candidates for targeted therapies due to their highly ...
Radiosynthesis and biological evaluation of [68Ga]Ga-NOTA-Folate in experimental atherosclerosis and myocardial infarction models.
(2020-05-12)
While many folate-receptor (FR) targeting radiotracers have been studied for imaging cancers, there is a need for tracers that target inflammation for diagnostic and monitoring purposes. Two diseases in which inflammation ...