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Aineistot 241-250 / 582
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(2020-05-11)
Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...
Cell signaling in breast cancer associated with neurofibromatosis type 1
(2020-04-30)
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...
Intracellular metabolism and transport of paclitaxel in ovarian cancer
(2020-04-30)
Although traditional chemotherapies are still the backbone of ovarian cancer treatment, interpatient variability in drug response and acquired resistance still present a major hurdle. The antimitotic agent, paclitaxel, is ...
Characterization of novel genes predominantly expressed in the epididymis – from genome analyses to genetically modified mice
(Annales Universitatis Turkuensis D 992Turun yliopisto, 2011-11-18)
In mammals, post-testicular sperm maturation taking place in the epididymis is required for the spermatozoa to acquire the abilities required to fertilize the egg <i>in vivo</i>. The epididymal epithelial cells secrete ...
The Integrin Tail: A Tale of Cell Motility and Division
(Annales Universitatis Turkuensis D 928Turun yliopisto, 2010-11-12)
Integrin transmembrane receptor functions are regulated by adaptor molecules binding to their alpha and beta subunit intracellular domains, or tails, thus affecting integrin traffic and adhesion during e.g. cell motility. ...
Comparison of Particle Sizing Methodologies in Non-clinical suspensions
(Turun yliopisto, 2017-08-08)
Factors Regulating Chondrogenic Differentiation
(Annales Universitatis Turkuensis D 938Turun yliopisto, 2010-12-10)
Chondrogenesis is a co-ordinated differentiation process in which mesenchymal cells condensate, differentiate into chondrocytes and begin to secrete molecules that form the extracellular matrix. It is regulated in a ...
Quantification of Proteins and Cells: Luminometric Nonspecific Particle-Based Methods
(Annales Universitatis Turkuensis D 952Turun yliopisto, 2011-03-25)
New luminometric particle-based methods were developed to quantify protein and to count cells. The developed methods rely on the interaction of the sample with nano- or microparticles and different principles of detection. ...
Antigen processing and intercellular trafficking in B cells
(Turun yliopisto, 2022-09-30)
B cells are responsible for specific antibody production. To produce antibodies, they recognize and internalize antigen (ag), cleave it into peptides, load the peptideantigens (pAg:s) onto major histocompatibility complex ...
Targeting JNKs with systemic viruses towards a mechanistic understanding of anxiety-like behaviour
(2022-09-05)
Depression and anxiety disorders are one of the most common mental health conditions. To develop better treatments for the disorders, it is necessary to understand their mechanisms better. Genetic aberrations on the c-Jun ...