Hae
Aineistot 21-30 / 578
SUMOylation regulates nuclear accumulation and signaling activity of the ErbB4 receptor tyrosine kinase
(2019-03-08)
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase–activated signaling cascades. Previously, ...
Gut microbes in the prevention and onset of metabolic disorders
(Turun yliopisto, 2019-06-14)
ABSTRACT:
Gut microbes are suggested to play an essential role in maintaining humanhealth, and unfavorable alterations in gut microbiota have been associated with several human diseases and disorders. Despite the ...
Development of male reproductive health in puberty and young adulthood
(Turun yliopisto, 2018-11-30)
The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
ANO7 in aggressive prostate cancer
(Turun yliopisto, 2020-03-13)
A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...
MicroRNA-mediated regulation of mitosis and taxane sensitivity in breast and ovarian cancer
(Turun yliopisto, 2017-11-24)
Taxanes are microtubule targeting chemotherapeutics that block cell division (mitosis) and induce cell death. Taxanes are commonly used in the neoadjuvant chemotherapy for breast and ovarian cancer. However, the patient ...
Role of PIM kinase-mediated regulation of Notch3 receptor protein in breast cancer
(Turun yliopisto, 2018-07-09)
Regulation of bone formation and post natal skeletal homeostasis - Novel role of Fam3c and osteoblast-specific Dicer1
(Turun yliopisto, 2017-10-06)
Development of the skeletal system comprises of two major biological processes namely, endochondral ossification and intramembranous ossification. Mesenchymal stromal cells give rise into bone forming osteoblasts, which ...
Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells
(2019-09-27)
Muscle invasive bladder cancer (BC) is a malignancy with a high mutational burden, mortality, and costs. Currently, the standard treatment combines cisplatin-based neoadjuvant chemotherapy (NAC) with radical cystectomy. ...
Gene Regulation in The Human Immune System. Gene Expression Signatures of Th2 Cell Differentiation, Type 1 Diabetes, and Intrauterine Immune Adaptation
(Annales Universitatis Turkuensis D 1138Turun yliopisto, 2014-11-28)
The human immune system is constantly interacting with the surrounding stimuli and microorganisms. However, when directed against self or harmless antigens, these vital defense mechanisms can cause great damage. In addition, ...
Regulation of Schwann cells and osteoclasts with an emphasis on NF1-deficient cells
(Turun yliopisto, 2019-06-08)
ABSTRACT
Neurofibromatosis type 1 (NF1) is a dominantly inherited cancer predisposition syndrome, which affects one in 2000 individuals worldwide. NF1 exhibits a variety of clinical symptoms. Neurofibromas, the hallmarks ...