Hae
Aineistot 21-30 / 151
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
Functional characterization of a humanized anti-Clever-1 antibody targeting monocytes and anti-inflammatory macrophages
(2018-11-29)
Targeting the immunosuppressive tumor microenvironment has gained interest in opening new avenues to fight against cancer growth. Macrophages are extremely potential candidates for targeted therapies due to their highly ...
Radiosynthesis and biological evaluation of [68Ga]Ga-NOTA-Folate in experimental atherosclerosis and myocardial infarction models.
(2020-05-12)
While many folate-receptor (FR) targeting radiotracers have been studied for imaging cancers, there is a need for tracers that target inflammation for diagnostic and monitoring purposes. Two diseases in which inflammation ...
IMAGE DERIVED INPUT FUNCTION FOR BRAIN [11C]TMSX PET IMAGING
(2019-04-05)
Modeling and analysis of positron emission tomography (PET) imaging data requires the critical information of the input function of the radioligand used. In PET imaging of the brain, the ‘gold standard’ for acquiring input ...
Neural Structures Associated with Music Engagement in Persons with Alzheimer’s Disease
(2020-06-01)
Alzheimer’s disease (AD) is the most common cause of dementia and a major public health issue resulting in decreased life expectancy of patients and high societal cost. Medical treatment of AD is palliative in nature as ...
Protein-encapsulated in mesoporous silica nanoparticles for the the treatment of bacterial biofilms
(2019-05-13)
80% of infections are estimated to be biofilm related, which are extremely resistant to anti-microbials. It remains an unmet need to develop medications to treat biofilms. Currently, there are evolving approaches that use ...
Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(2020-05-06)
The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(2020-05-11)
Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...
Cell signaling in breast cancer associated with neurofibromatosis type 1
(2020-04-30)
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...
Intracellular metabolism and transport of paclitaxel in ovarian cancer
(2020-04-30)
Although traditional chemotherapies are still the backbone of ovarian cancer treatment, interpatient variability in drug response and acquired resistance still present a major hurdle. The antimitotic agent, paclitaxel, is ...