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Aineistot 31-40 / 89
Peptide-based drug discovery tools for protein post-translational modifications
(Turun yliopisto, 2021-02-26)
Bringing a new drug to the market is an expensive and long process. Typically, more than ten years and a billion dollars needs to be spent so the whole process is a big investment for a pharma company. The hit generation ...
The optical and magnetic properties of redox-active d-block metal complexes with non-innocent ligands
(Turun yliopisto, 2021-02-19)
Redox-active metal organic complexes with ‘non-innocent’ ligands are promising candidates when it comes to developing novel homogenous catalysts. The related complexes have gained interest since they could be utilized as ...
Label-free methods for studying protein-protein interactions
(Turun yliopisto, 2021-12-17)
Proteins are the building blocks of life, and mainly perform their roles through protein-protein interactions (PPIs). Thus, PPIs are essential to the normal function of the cells and the body, and disturbances in these ...
Fluorescent and 19F NMR probes for metal-mediated base pairing
(Turun yliopisto, 2022-03-04)
Research on metal-mediated base pairing has proceeded rapidly during the last decades, and metal-mediated base pairs have become one noteworthy option for developing new DNA-based biological or nanotechnological applications. ...
Detection and quantification of silica dust in filtered air samples
(2021-05-13)
Silica is a common mineral in nature. Quartz is the most common form of silica in earth’s crust, while cristobalite and tridymite rarely occur. Quartz can be found in a variety of rocks and soils, and in products such as ...
Photochromic Sodalites by a New Method of Synthesis
(2021-11-12)
Photochromic sodalites, also known as hackmanites, are minerals that belong to the sodalite mineral group and have a general formula of Na8(SiAlO4)6(Cl,S)2. Hackmanites can exhibit reversible photochromism i.e., tenebrescence, ...
ViLLE-pohjainen pakopeli opetuskäyttöön
(2021-12-21)
Tässä tutkimuksessa kehitettiin ViLLE-oppimisympäristössä toimiva pakopeli. Tutkimusmenetelmänä käytettiin kehittämistutkimusta, jonka avulla pyrittiin vastaamaan kehittämistutkimuksen ongelma-analyysistä ja kehittämisprosessista ...
Towards cyclopalladated therapeutic oligonucleotides
(Turun yliopisto, 2021-11-19)
Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...
Recognition of single- and double-stranded nucleic acids by covalently mercurated oligonucleotides
(Turun yliopisto, 2021-03-02)
Metal-mediated base pairs have attracted considerable attention during the past decades for their potential in bio- and nanotechnological applications. The introduction of metal ions into DNA or RNA not only stabilizes ...
Evaluation of an ‘open box’ undergraduate laboratory experiment for understanding how a UV-Vis spectrometer works
(2021-03-13)
In this study, a novel ‘open box’ spectrometer experiment that was introduced in a first-year undergraduate chemistry laboratory course in Durham University in 2018 was evaluated with the aim to determine its success and ...