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Synthesis of Short Oligonucleotides on a Soluble Support by the Phosphoramidite Method
(Turun yliopistoAnnales Universitatis Turkuensis A I 521, 2015-09-04)
In the last decades, the chemical synthesis of short oligonucleotides has become an important aspect of study due to the discovery of new functions for nucleic acids such as antisense oligonucleotides (ASOs), aptamers, ...
Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns
(Turun yliopistoAnnales Universitatis Turkuensis A I 494, 2014-11-07)
Ribonucleic acid (RNA) has many biological roles in cells: it takes part in coding, decoding, regulating and expressing of the genes as well as has the capacity to work as a catalyst in numerous biological reactions. These ...
Covalent conjugates of therapeutic oligonucleotides for in vivo targeting
(Turun yliopistoAnnales Universitatis Turkuensis A I 546, 2016-09-30)
Over last few years, the development of oligonucleotide based therapeutics (antisense, siRNA, antagomirs) have received much interest as a novel class of drugs for the treatment of many diseases. Cell/organ ...