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Role of cancerous inhibitor of protein phosphatase 2A in the regulation of T-cell response
(Turun yliopisto, 2021-12-03)
T helper (Th) cell subsets with distinct functions are a critical component of the adaptive immune system. Th17 cells secrete interleukin 17 (IL-17) and provide host defense against pathogens. However, dysregulated Th17 ...
Alpha- and gamma-melanocyte stimulating hormones in obesity. A study of the key central areas of metabolic regulation
(Annales Universitatis Turkuensis D 1128Turun yliopisto, 2014-09-19)
The melanocortin system is an important regulator of feeding, energy metabolism,and cardiovascular function and it consists of the pro-opiomelanocortin (POMC) derived melanocyte stimulating hormones (α-, β- and γ-MSH) and ...
Histological detection and prognostic value of regulators of metaphase-anaphase transition in breast cancer
(Turun yliopisto, 2018-12-14)
The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...
Formin proteins in normal tissues and cancer
(Annales Universitatis Turkuensis D 1161Turun yliopisto, 2015-03-13)
The actin cytoskeleton is a dynamic structure that determines cell shape. Actin turnover is mandatory for migration in normal and malignant cells. In epithelial cancers invasion is frequently accompanied by epithelial to ...
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
(Turun yliopisto, 2018-11-16)
The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...
Novel genes and regulatory systems in epididymal differentiation and sperm maturation of the mouse.
(Annales Universitatis Turkuensis D 1151Turun yliopisto, 2014-12-12)
Mammalian spermatozoa gain their fertilizing ability during maturation in the epididymis. Proteins and lipids secreted into the epididymal lumen remodel the sperm membrane, thereby providing the structure necessary for ...
Securin-related cell proliferation in breast cancer prognosis
(Turun yliopisto, 2020-03-13)
Breast cancer is the most common malignancy among women. It remains a major cause of mortality among women, although the five-year survival of breast cancer patients is about 90%. To aid in the clinical treatment decisions, ...
Regulation of Spermatogenesis: Differentiation of GFP-labeled Stem Cells and the Function of Cytoplasmic Bridges
(Turun yliopisto, 2003)
During spermatogenesis, different genes are expressed in a strictly coordinated fashion providing an excellent model to study cell differentiation. Recent identification of testis specific genes and the development of green ...
ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models
(Turun yliopisto, 2018-06-15)
Abstract:
Prostate cancer is a major global challenge due to the increasing number of aging population
and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic
prostate cancer is responsive ...
Luukudoksen ja elimistön energiametabolian yhteys
(Turun yliopisto, 2016-03-31)