Hae
Aineistot 31-40 / 223
Formin proteins in normal tissues and cancer
(Annales Universitatis Turkuensis D 1161Turun yliopisto, 2015-03-13)
The actin cytoskeleton is a dynamic structure that determines cell shape. Actin turnover is mandatory for migration in normal and malignant cells. In epithelial cancers invasion is frequently accompanied by epithelial to ...
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
(Turun yliopisto, 2018-11-16)
The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...
Novel genes and regulatory systems in epididymal differentiation and sperm maturation of the mouse.
(Annales Universitatis Turkuensis D 1151Turun yliopisto, 2014-12-12)
Mammalian spermatozoa gain their fertilizing ability during maturation in the epididymis. Proteins and lipids secreted into the epididymal lumen remodel the sperm membrane, thereby providing the structure necessary for ...
Securin-related cell proliferation in breast cancer prognosis
(Turun yliopisto, 2020-03-13)
Breast cancer is the most common malignancy among women. It remains a major cause of mortality among women, although the five-year survival of breast cancer patients is about 90%. To aid in the clinical treatment decisions, ...
Regulation of Spermatogenesis: Differentiation of GFP-labeled Stem Cells and the Function of Cytoplasmic Bridges
(Turun yliopisto, 2003)
During spermatogenesis, different genes are expressed in a strictly coordinated fashion providing an excellent model to study cell differentiation. Recent identification of testis specific genes and the development of green ...
ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models
(Turun yliopisto, 2018-06-15)
Abstract:
Prostate cancer is a major global challenge due to the increasing number of aging population
and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic
prostate cancer is responsive ...
Lyme borreliosis in Finland : studies on environmental exposure, disease susceptibility and epidemiology
(Turun yliopisto, 2017-10-13)
Lyme borreliosis is the most common tick-borne infectious disease in Europe and North America. It is caused by the spirochetes belonging to the Borrelia burgdorferi sensu latocomplex. The bacteria are transmitted to humans ...
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
(Turun yliopisto, 2018-01-26)
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroidmetabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed ...
Regulation of human aromatase gene expression in adipose tissue
(2020-02-29)
The conversion of androgens to estrogens is catalyzed by the aromatase enzyme, the product of the CYP19A1 gene, in gonads and peripheral tissues. Estrogens produced in the white adipose tissue (WAT) are postulated to play ...
Regulation of gonadal steroid synthesis and reproduction : novel roles of hydroxysteroid (17β) dehydrogenase 1
(Turun yliopisto, 2017-12-15)
Estrogens and androgens are critical regulators of several physiological processes,including development and reproduction. In addition, these hormones play key roles in several physiological complications and diseases, ...