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Novel PP2A biomarkers in cancer
(Turun yliopisto, 2021-04-09)
Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited ...
Cellular vulnerabilities of glioblastoma
(Turun yliopisto, 2021-10-15)
Glioblastoma (GB) is the most fatal and frequent malignant brain tumor, and it is driven by multiple oncogenic pathways. Despite intensive screening of genomic, transcriptomic, metabolic, and post-translational landscape ...