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Aineistot 481-490 / 578
Initiation of New Medication With an Actionable Pharmacogenetics-Based Prescribing Guideline in Discharged Hospital Patients in Finland
(2021-05-07)
OBJECTIVES. Purpose of this retrospective, register-based pharmacoepidemiologic study was to analyse post-discharge purchases of drugs with an actionable pharmacogenetics-based prescribing guideline with a patient cohort ...
The effect of melanocortin-1 receptor deficiency on cholesterol transporter genes in atherosclerotic ApoE knockout mouse model
(Turun yliopisto, 2017-07-20)
The melanocortin system comprises of melanocortin peptides; α-, β- and γ- melanocortin stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) derived from the proteolytic degradation ...
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(2021-05-10)
Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...
The effects of the combination treatment of AR and FGFR inhibitors in prostate cancer
(2021-05-18)
Androgen receptor (AR) signaling is key for prostate cancer (PrCa) progression. Androgen deprivation therapy is not curative if PrCa progresses to advanced, castration-resistant PrCa and androgen-independent cancers. ...
Novel PP2A biomarkers in cancer
(Turun yliopisto, 2021-04-09)
Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited ...
Genetics of inherited dementing disorders – Special emphasis on Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease and primary familial brain calcification
(Annales Universitatis Turkuensis D 1266Turun yliopisto, 2017-01-21)
Advances in genotyping and sequencing technologies have enabled the identification of common and rare genetic variation associated with dementia. This thesis aimed to examine the genetic background of ...
New perspectives on the melanocortins and their cardiovascular effects: Potential implications for the treatment of cardiovascular diseases with melanocortin analogues
(Annales Universitatis Turkuensis D 1050Turun yliopisto, 2013-01-11)
The melanocortin peptides, including melanocyte-stimulating hormones, α-, β- and
γ-MSH, are derived from the precursor peptide proopiomelanocortin and mediate their
biological actions via five different melanocortin ...
Mechanisms of aging induced decline in wound healing
(2020-09-22)
The impaired wound healing is a significant concern affecting millions of people worldwide. The increased incidence is mainly caused by growing number of aged individuals, whose potential to repair tissues and healing of ...
Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...
Identification of predictive ERBB mutations for targeted treatment
(Turun yliopisto, 2023-05-26)
Predictive biomarkers, such as genetic alterations, are used in personalized cancer medicine to target treatment. Genes encoding members of the ERBB family of receptor tyrosine kinases are well known to harbor genetic ...