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Effects of 27-hydroxycholesterol on oligodendrocytes in Alzheimer’s disease: a double-edged sword?
(2020-05-04)
Hypercholesterolemia is an established risk factor for developing Alzheimer’s disease (AD). A proposed link between elevated systemic cholesterol levels and AD is oxysterols: oxidized metabolites of cholesterol, which can ...
DNA repair genes in prostate cancer : the characterization of novel molecular mechanisms
(2020-05-18)
Prostate cancer is one of the major causes of cancer-related deaths in males in Western countries. Androgen deprivation therapy is a standard treatment for metastatic prostate cancer, aiming to suppress androgen receptor ...
In vitro bioactivity profile analysis and evaluation of usability of bioactive glass fibers as a structural part in load-bearing implants
(2020-12-08)
Metallic and permanent bone implants expose trauma patients to recurring fractures and infections even after years of implantation. Metallic implants also predispose for stress shielding phenomenon and fibrous capsule ...
Modulation of monocyte inflammatory response through estrogen receptor α and progesterone receptor signaling
(2021-04-06)
Ovarian hormone fluctuation has been associated to clinical status of several autoimmune conditions and the influence on inflammatory disease is under investigation. The incidence of inflammatory bowel disease is high in ...
Establishment of in vitro breast cancer bone metastasis model using an artificial microenvironment
(2021-03-11)
Advanced breast cancer frequently metastasises to the bone, causing considerable morbidity to the patients. Survival rate after detection of bone metastases is poor, and options to treat bone metastases are insufficient. ...
Blocking Clever-1 on human monocytes inhibits the growth of aggressive breast cancer
(2019-07-31)
Immunosuppressive tumor microenvironment limits antitumoral immunity and facilitates cancer progression. Tumor-associated macrophages that are mainly derived from blood monocytes, are central regulators of the tumor immune ...
Reproductive analysis of HSD17B3 knockout mice
(2019-01-08)
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme responsible for the conversion of androstenedione to testosterone in testes, and thus important for male sexual development, maturation ...
Identification of RasGEFs counteracting neuronal SynGAP1 function
(2021-05-11)
SynGAP syndrome refers to an under-diagnosed group of diseases caused by the mutation of the SynGAP1 gene encoding the predominant synaptic protein SynGAP1. SynGAP1 is a Ras GTPase activating protein that is a major regulator ...
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
(2019-02-05)
Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...
Transport of statins by human ABC efflux transporters in vitro
(2021-04-26)
Transporters are cell membrane proteins, which mediate the cellular influx or efflux of compounds. Transporters expressed in tissues important for pharmacokinetics, can play a crucial role in drug absorption, distribution ...