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Aineistot 51-60 / 248
Innate immune system as the driver of Rheumatoid Arthritis
(Turun yliopisto, 2017-12-02)
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease traditionally believed to be driven primarily by the adaptive immune cells. However, a large infiltrate of innate cells can be seen in the inflamed ...
Regulation of B cell development by transcription factors IRF4 and BACH2
(Turun yliopisto, 2017-10-20)
B lymphocytes—major cell types mediating an adaptive immunity—recognize a vast variety of structures by B cell antigen receptors (BCR). Activated B cells can form germinal centers, undergo antigen-induced affinity maturation ...
Identification of novel genes involved in the pathophysiology of adrenocortical tumorigenesis
(Turun yliopisto, 2017-12-01)
Adrenocortical tumors (ACT) are relatively common, with a prevalence of 6% in the aging population. They can be divided into benign adenomas (ACA) and malignant carcinomas (ACC). Tumors responding to luteinizing hormone ...
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
(Turun yliopisto, 2018-01-19)
At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ...
Biomarkers in stage II colorectal cancer
(Turun yliopisto, 2020-02-21)
The risk of recurrence of stage II colorectal cancer is difficult to predict. A part of recurrences take place among patients without any of the known high-risk factors such as lymphovascular invasion or preoperative ...
Association between intrathoracic adipose tissue mass and metabolic parameters
(Turun yliopisto, 2018-05-30)
Overweight or obesity, along with type 2 diabetes mellitus, is one of the major causes of cardiovascular morbidity and mortality. In the heart, fat is deposited inside – myocardial triglyceride content, and outside the ...
Genetics of inherited small vessel diseases – in search of a novel small vessel disease and modifiers of the clinical course of CADASIL
(Annales Universitatis Turkuensis D 1198Turun yliopisto, 2015-11-21)
The genetic and environmental risk factors of vascular cognitive impairment are still largely unknown. This thesis aimed to assess the genetic background of two clinically similar familial small vessel ...
Multi-omics analysis of early molecular mechanisms of type 1 diabetes
(Turun yliopisto, 2021-12-17)
Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ...
The Chromatoid body entourage: Molecular characterization of the Chromatoid body‐associated cytoplasmic vesicles
(Turun yliopisto, 2015-11-27)
Spermatogenesis is a unique process compared to cell differentiation in somatic tissues. Germ cells undergo a considerable number of metabolic and morphological changes during their differentiation: they initially ...
The effects of mutated cationic amino acid transporter y+LAT1 at the cellular and systemic level
(Annales Universitatis Turkuensis D 1204Turun yliopisto, 2015-11-27)
y+LAT1 is a transmembrane protein that, together with the 4F2hc cell surface antigen, forms a transporter for cationic amino acids in the basolateral plasma membrane of epithelial cells. It is mainly expressed in the kidney ...