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Aineistot 61-70 / 248
The Role of DbpA and B adhesins in the pathogenesis of Lyme borreliosis
(Annales Universitatis Turkuensis D 1248Turun yliopisto, 2016-09-30)
Lyme borreliosis is a tick-borne infectious disease common in the Northern hemisphere. It is most commonly caused by B. burgdorferi sensu stricto, B. garinii or B. afzelii. The Borrelia bacteria ...
Interactions between Human Mesenchymal Stem Cells and Circulating Mononuclear Cells in Bone Regeneration
(Annales Universitatis Turkuensis D 1250Turun yliopisto, 2016-10-12)
Despite the regenerative actions of bone marrow mesenchymal stem cells (BM-MSCs) and optimal reduction, ossification is delayed in almost 10% of all fractures, requiring surgical intervention. The gold standard for treating ...
New Roads to Genomic Imbalance: Microrna- and Protein Phosphatase-Mediated Regulation of Mitosis
(Annales Universitatis Turkuensis D 1243Turun yliopisto, 2016-09-16)
The Spindle Assembly Checkpoint (SAC) works to maintain the genomic balance by monitoring the correctness of attachments between the chromosomes and microtubules during early cell division (mitosis). Importantly, chromosome ...
Expectations, frames and practices of genetic counselling in different contexts of genetic testing
(Annales Universitatis Turkuensis D 1130Turun yliopisto, 2014-09-26)
Genetic counselling is a process in which the counsellee receives information and support concerning a genetic disease. This study examines the genetic counselling attached to genetic testing. Since genetic information is ...
In vivo tsoledronaatin ja murtuman vaikutus rotan mesenkymaalisten kantasolujen ex vivo jakautumiseen ja erilaistumiseen osteoblasteiksi
(Turun yliopisto, 2017-08-07)
Bisfosfonaatit, kuten tsoledronaatti, estävät osteoklastien toimintaa, minkä takia niitä käytetään osteoporoosin hoidossa. Bisfosfonaattien on havaittu vaikuttavan myös osteoblasteihin, mutta tämän vaikutuksen merkitys on ...
The alpha2C-adrenoceptor as a neuropsychiatric drug tar-get - PET studies in human subjects
(Annales Universitatis Turkuensis D 1209Turun yliopisto, 2015-12-11)
Positron emission tomography imaging has both academic and applied uses in revealing the distribution and density of different molecular targets in the central nervous system. Following the significant progress made with ...
Modulation of TGF-β signaling by Hypoxia
(Annales Universitatis Turkuensis D 1203Turun yliopisto, 2015-12-11)
A tumor is a fast-growing malignant tissue. This creates areas inside the tumor that are distant from local blood vessels to be able to get enough oxygen. This hypoxic condition activates a transcription factor called ...
Players of Th-cell differentiation and immune dysregulation – focus on GIMAP family genes
(Annales Universitatis Turkuensis D 1183Turun yliopisto, 2015-09-15)
The balance of T helper (Th) cell differentiation is the fundamental process that ensures that the immune system functions correctly and effectively. The differentiation is a fine tuned event, the outcome of ...
From epithelial to mesenchymal: regulation of invasive cancer cell motility
(Annales Universitatis Turkuensis D 1205Turun yliopisto, 2015-12-04)
Metastasis is the main cause of death among cancer patients. In order to initiate the metastatic cascade cancer cells have to undergo epithelial-to-mesenchymal transition (EMT). In EMT epithelial cells ...
Detection, Identification and Molecular Variation of Human Enteroviruses
(Annales Universitatis Turkuensis D 1201Turun yliopisto, 2015-11-28)
Picornaviruses are the most common human viruses and the identification of the picornaviruses is nowadays based on molecular techniques, for example, reverse transcriptase polymerase ...