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Synthesis of 18F-labelled radiopharmaceuticals for CNS imaging : From radiosynthesis development to GMP production
(Turun yliopisto, 2021-03-19)
Positron emission tomography (PET) is an imaging technique that can be used to follow various biological processes, such as receptor function, in a living body. PET utilisesradiopharmaceuticals, tracers containing short-lived ...
Peptide-based drug discovery tools for protein post-translational modifications
(Turun yliopisto, 2021-02-26)
Bringing a new drug to the market is an expensive and long process. Typically, more than ten years and a billion dollars needs to be spent so the whole process is a big investment for a pharma company. The hit generation ...
Recognition of single- and double-stranded nucleic acids by covalently mercurated oligonucleotides
(Turun yliopisto, 2021-03-02)
Metal-mediated base pairs have attracted considerable attention during the past decades for their potential in bio- and nanotechnological applications. The introduction of metal ions into DNA or RNA not only stabilizes ...
The optical and magnetic properties of redox-active d-block metal complexes with non-innocent ligands
(Turun yliopisto, 2021-02-19)
Redox-active metal organic complexes with ‘non-innocent’ ligands are promising candidates when it comes to developing novel homogenous catalysts. The related complexes have gained interest since they could be utilized as ...
Aminophenolato complexes of Mo, W and V In catalytic alkene epoxidation and catechol oxidation
(Turun yliopisto, 2021-11-05)
Mo, W and V are found naturally in metalloenzymes such as the Mo/W oxotransferases and the V haloperoxidases (VHPOs). These enzymes catalyze oxidation reactions related to C, N, S metabolism as well as halogenation. Cu and ...