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The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...

Background: High-intensity acute exercise is known to induce oxidative stress and may lead to harmful oxidation of lipids, and protein and DNA damage. On the other hand, exercise is known to positively influence risk factors ...

The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...

Because of the heavily overlapping symptoms, pathogen-specific diagnosis and treatment of infectious diseases is difficult based on clinical symptoms alone. Therefore, patients are often treated empirically. More efficient ...

The detection of early markers is the key issue in predicting the outcome of inflammatory diseases such as type 1 diabetes and atherosclerosis. Whilst biochemical testing approaches have improved prediction of inflammatory ...

The HLA region accounts for approximately half of the genetic susceptibility in type 1 diabetes. The strongest genetic association with type 1 diabetes (T1D) is conferred by HLA class II alleles, where particular combinations ...

Plasma membrane receptors play an essential role in cancer by regulating cancer-related processes such as cell proliferation and migration in response to cues from the extracellular ligands. Integrins are cell-matrix ...

Bone is a physiologically dynamic tissue being constantly regenerated throughout life as a consequence of bone turnover by bone-resorbing osteoclasts and bone-forming osteoblasts. In certain bone diseases, such as osteoporosis, ...

Cells communicate, or signal, with each other constantly to ensure proper functioning of tissues and organs. Cell signaling is often performed by interplay of receptors and ligands that bind these receptors. ErbB receptors ...

Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome caused by mutations in the large and complex NF1 tumor suppressor gene on chromosome 17. NF1 is the most frequent hereditary tumor predisposition syndrome. ...