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Development of male reproductive health in puberty and young adulthood
(Turun yliopisto, 2018-11-30)
The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
The effect of training background on oxidized lipoprotein lipids and antioxidant capacity in athletes and keep-fit runners
(Turun yliopisto, 2018-12-07)
Background: High-intensity acute exercise is known to induce oxidative stress and may lead to harmful oxidation of lipids, and protein and DNA damage. On the other hand, exercise is known to positively influence risk factors ...
Histological detection and prognostic value of regulators of metaphase-anaphase transition in breast cancer
(Turun yliopisto, 2018-12-14)
The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...
Two-photon excitation fluorometry in detection of infectious diseases
(Annales Universitatis Turkuensis AI 384Turun yliopisto, 2008-11-21)
Because of the heavily overlapping symptoms, pathogen-specific diagnosis and treatment of infectious diseases is difficult based on clinical symptoms alone. Therefore, patients are often treated empirically. More efficient ...
Serum proteomics to detect early changes in type 1 diabetes and carotid atherosclerosis
(Turun yliopisto, 2018-10-10)
The detection of early markers is the key issue in predicting the outcome of inflammatory diseases such as type 1 diabetes and atherosclerosis. Whilst biochemical testing approaches have improved prediction of inflammatory ...
Polymorphisms and genetic susceptibility of Type 1 diabetes and Addison’s disease
(Turun yliopisto, 2018-11-23)
The HLA region accounts for approximately half of the genetic susceptibility in type 1 diabetes. The strongest genetic association with type 1 diabetes (T1D) is conferred by HLA class II alleles, where particular combinations ...
New insights into receptor trafficking in human cancer
(Turun yliopisto, 2018-11-16)
Plasma membrane receptors play an essential role in cancer by regulating cancer-related processes such as cell proliferation and migration in response to cues from the extracellular ligands. Integrins are cell-matrix ...
Tartrate-Resistant Acid Phosphatase 5b: a Serum Marker of Bone Resorption
(Turun yliopisto, 2004)
Bone is a physiologically dynamic tissue being constantly regenerated throughout life as a consequence of bone turnover by bone-resorbing osteoclasts and bone-forming osteoblasts. In certain bone diseases, such as osteoporosis, ...
Novel Functions of ErbB4 and NRG-1 in Development and Cancer
(Annales Universitatis Turkuensis D 1060Turun yliopisto, 2013-03-22)
Cells communicate, or signal, with each other constantly to ensure proper functioning of tissues and organs. Cell signaling is often performed by interplay of receptors and ligands that bind these receptors. ErbB receptors ...
Neurofibromatosis type 1: From gene to population and cancer
(Turun yliopisto, 2018-03-23)
Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome caused by mutations in the large and complex NF1 tumor suppressor gene on chromosome 17. NF1 is the most frequent hereditary tumor predisposition syndrome. ...