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The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...

Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ...

The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...

Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...

The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...

In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ...

Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ...