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Serum proteomics to detect early changes in type 1 diabetes and carotid atherosclerosis
(Turun yliopisto, 2018-10-10)
The detection of early markers is the key issue in predicting the outcome of inflammatory diseases such as type 1 diabetes and atherosclerosis. Whilst biochemical testing approaches have improved prediction of inflammatory ...
Polymorphisms and genetic susceptibility of Type 1 diabetes and Addison’s disease
(Turun yliopisto, 2018-11-23)
The HLA region accounts for approximately half of the genetic susceptibility in type 1 diabetes. The strongest genetic association with type 1 diabetes (T1D) is conferred by HLA class II alleles, where particular combinations ...
Novel regulators of T helper cell differentiation con-tribute to autoimmune inflammation
(Turun yliopisto, 2018-09-14)
T helper cells are critical components of adaptive immune system contributing to self/ nonself-recognition, pathogen elimination and pathogenesis of immune-associated diseases.
Understanding the underlying mechanisms ...
Vascular adhesion protein-1, its ligands and role in cardiovascular disease prediction
(Turun yliopisto, 2018-09-21)
To study the pathogenesis and prevention of diseases, population studies in which hundreds of measurements are done from the same persons have a crucial role. A biomarker is any measurable characteristic that gives information ...
Studies on the pathogenesis and laboratory diagnosis of Lyme borreliosis
(Turun yliopisto, 2019-01-18)
Lyme borreliosis, the most common tick-borne disease in the northern hemisphere, is caused by Borrelia burgdorferi sensu lato spirochetes (later Borrelia). They can infect humans through bites of infected Ixodes ticks. If ...
Innate immune system as the driver of Rheumatoid Arthritis
(Turun yliopisto, 2017-12-02)
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease traditionally believed to be driven primarily by the adaptive immune cells. However, a large infiltrate of innate cells can be seen in the inflamed ...
Lyme borreliosis in Finland : studies on environmental exposure, disease susceptibility and epidemiology
(Turun yliopisto, 2017-10-13)
Lyme borreliosis is the most common tick-borne infectious disease in Europe and North America. It is caused by the spirochetes belonging to the Borrelia burgdorferi sensu latocomplex. The bacteria are transmitted to humans ...
Regulation of B cell development by transcription factors IRF4 and BACH2
(Turun yliopisto, 2017-10-20)
B lymphocytes—major cell types mediating an adaptive immunity—recognize a vast variety of structures by B cell antigen receptors (BCR). Activated B cells can form germinal centers, undergo antigen-induced affinity maturation ...
Intestinal permeability in pregnancy : dietary and microbial determinants and metabolic consequences
(Turun yliopisto, 2017-11-10)
Metabolic disorders during pregnancy may challenge the mother and child to longterm health complications. Emerging data indicates a link between increased intestinal permeability and metabolic risk markers in a non-pregnant ...
Studies on the pathogenesis and historical seroprevalence of Lyme borreliosis in Finland
(Turun yliopisto, 2020-03-13)
Lyme borreliosis (LB) is a common tick-borne infectious disease in the Northern Hemisphere. The LB causing Borrelia burgdorferi sensu lato (Borrelia) spirochetes enter the human host via the tick bite. From the initial ...