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SUMOylation regulates nuclear accumulation and signaling activity of the ErbB4 receptor tyrosine kinase
(2019-03-08)
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase–activated signaling cascades. Previously, ...
PARP Inhibitors in Prostate Cancer – The Preclinical Rationale and Current Clinical Development
(2020-03-17)
Prostate cancer is the second most commonly diagnosed cancer type in men in the Western world. The majority of prostate cancer patients have a good prognosis, while some prostate cancers advance locally or metastasize. ...
Novel approaches for ErbB receptor tyrosine kinase inhibition
(2020-12-14)
ErbB receptor tyrosine kinases are cell-surface proteins that regulate cell proliferation, differentiation, and survival. The four ErbB family members – EGFR, ErbB2, ErbB3 and ErbB4 – function abnormally in certain types ...
The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration
(2020-12-14)
ERBB4 is a cell surface receptor that belongs to the ERBB family of receptor tyrosine kinases. Binding of a ligand to the extracellular domain leads to the activation of the intracellular kinase domain and autophosphorylation ...