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New functions for the cellular oxygen sensor PHD3 in clear cell renal cell carcinoma
(Turun yliopisto, 2018-05-18)
The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...
SUMOylation regulates nuclear accumulation and signaling activity of the ErbB4 receptor tyrosine kinase
(2019-03-08)
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase–activated signaling cascades. Previously, ...
ANO7 in aggressive prostate cancer
(Turun yliopisto, 2020-03-13)
A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...
Expression and role of decorin in human epithelial cancers - with special reference to bladder, colon and vulva carcinomas
(Turun yliopisto, 2019-05-11)
Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop
therapies for skeletal disorders and articular cartilage defects or disorders like
osteoarthritis (OA). Specific properties of each ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-15)
PARP Inhibitors in Prostate Cancer – The Preclinical Rationale and Current Clinical Development
(2020-03-17)
Prostate cancer is the second most commonly diagnosed cancer type in men in the Western world. The majority of prostate cancer patients have a good prognosis, while some prostate cancers advance locally or metastasize. ...
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos
(2020-01-23)
Reseptorityrosiinikinaasit (RTK) ovat kasvutekijäreseptoreita, jotka välittävät solujen kasvua, erilaistumista ja selviytymistä. RTK:en yli-ilmentyminen ja mutaatiot ovatkin tavallista erilaisissa sairauksissa, kuten ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-17)
Screening fungal lectin activities from mushroom extracts with special reference on the Inocybe lectin and its specificity
(2019-05-24)
The aim of this study was to screen mushroom extracts in search of lectin activities. This was carried out by homogenizing total amount of 129 mushroom samples and measuring their hemagglutination and hemolysis when mixed ...