Acute respiratory infections in early childhood and risk of asthma at age 7 years
Forsström, Ville (2019-02-08)
Acute respiratory infections in early childhood and risk of asthma at age 7 years
(08.02.2019)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe201902114581
https://urn.fi/URN:NBN:fi-fe201902114581
Tiivistelmä
Young children experience frequent acute respiratory infections (ARIs). Of these, lower respiratory tract infections are
associated with an increased risk of developing childhood asthma. The association between upper respiratory infections and
subsequent childhood asthma is not yet equally well understood.
In this study, 923 children were followed with symptom diaries for ARIs from birth until two years of age. During ARIs, nasal swabs for respiratory viruses were acquired. Primary outcome was a diagnosed asthma in electronic medical records or a
prescription for an inhalation corticosteroid at 6.5 to 7.5 years of age. The association between ARIs and the risk of asthma was evaluated using binary logistic regression analysis.
Electronic prescriptions and medical records were available for 910 (99%) children. A total of 8795 ARIs were recorded, with a mean number of 6.2 (95% confidence interval [CI] 6.0-6.4) per child per year. Asthma was documented at age 7 years in 75 (8%) children. Increased number of ARIs (≥9/year vs <5/year) during 0-2 years of age was associated with an increased risk of asthma at age 7 (adjusted odds ratio 7.20, 95% CI 2.49‒20.88), as were more severe and prolonged ARIs. Children who developed asthma had more days with ARI symptoms per year before 2 years of age than other children (mean 65 vs 50, p=0.01).
We found an association between early childhood ARIs and later childhood asthma. This association may stem from common pathophysiologic mechanisms, or ARIs in early childhood may be a predisposing factor to the development of asthma.
associated with an increased risk of developing childhood asthma. The association between upper respiratory infections and
subsequent childhood asthma is not yet equally well understood.
In this study, 923 children were followed with symptom diaries for ARIs from birth until two years of age. During ARIs, nasal swabs for respiratory viruses were acquired. Primary outcome was a diagnosed asthma in electronic medical records or a
prescription for an inhalation corticosteroid at 6.5 to 7.5 years of age. The association between ARIs and the risk of asthma was evaluated using binary logistic regression analysis.
Electronic prescriptions and medical records were available for 910 (99%) children. A total of 8795 ARIs were recorded, with a mean number of 6.2 (95% confidence interval [CI] 6.0-6.4) per child per year. Asthma was documented at age 7 years in 75 (8%) children. Increased number of ARIs (≥9/year vs <5/year) during 0-2 years of age was associated with an increased risk of asthma at age 7 (adjusted odds ratio 7.20, 95% CI 2.49‒20.88), as were more severe and prolonged ARIs. Children who developed asthma had more days with ARI symptoms per year before 2 years of age than other children (mean 65 vs 50, p=0.01).
We found an association between early childhood ARIs and later childhood asthma. This association may stem from common pathophysiologic mechanisms, or ARIs in early childhood may be a predisposing factor to the development of asthma.