Julkaisuarkisto
Viimeksi lisätyt
- Ladataan...The economic burden of inflammatory bowel disease
ArtikkeliväitöskirjaRankala, Rasmus
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1990 (Turun yliopisto, 2026-08-21)Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative coli-tis, are chronic illnesses that impose a considerable economic burden on patients, health care providers, and society. As onset of IBD is typically during the working age and requires ongoing medical management, its costs extend beyond health care expenditures and have a broader societal impact, such as in reduced productivity. As IBD is becoming more prevalent worldwide, understanding its total economic bur-den is increasingly important. This thesis aimed to assess the economic burden of IBD from multiple perspec-tives, including from health care providers, patients, and from society. Key focus areas included direct medical costs, patient medication costs, and productivity losses due to absenteeism and presenteeism. The study population was collected from IBD patients who visited Turku Uni-versity Hospital during a one-year study period. A randomized half of the patients received a questionnaire, and for respondents, clinical and treatment data were col-lected and linked to their responses, enabling combined analysis of registry-based and patient reported data. The results showed that IBD generates considerable costs across all observed domains. Health care visits, drug therapies, and productivity losses each contributed meaningfully to the total burden. While a small number of patients accounted for a disproportionally large share of total expenses, the overall economic impact was widely distributed. These findings highlight the need to consider both direct and indirect costs in IBD cost evaluations. Using real-world registry and questionnaire data offered a strong basis for identifying key cost drivers and that could help guide future studies that determine cost effectiveness in drug management and to shape policy decisions.Tulehdukselliset suolistosairaudet (IBDt), kuten Crohnin tauti ja haavainen paksu-suolitulehdus ovat kroonisia sairauksia, jotka aiheuttavat merkittävän taloudellisen taakan potilaille, terveydenhuollolle ja yhteiskunnalle. Koska IBDt alkavat tyypilli-sesti työiässä niiden kustannukset ulottuvat terveydenhuoltomenojen lisäksi työky-vyn heikkenemisestä johtuviin tuottavuustappioihin. IBD:n yleistyessä maailman-laajuisesti sairauden kokonaiskustannusten ymmärtäminen on yhä tärkeämpää. Tämän tutkimuksen tavoitteena oli arvioida IBD:n aiheuttamaa kokonaistaakkaa potilaiden, terveydenhuollon ja yhteiskunnan näkökulmasta. Tarkastelussa painot-tuivat suorat hoitokustannukset, potilaiden lääkekustannukset sekä työkyvyn mene-tyksestä johtuvat kustannukset, kuten poissaolot ja alentunut työteho. Tutkimusaineisto kerättiin Turun yliopistollisessa keskussairaalassa käyneistä IBD-potilaista vuoden aikana. Satunnaisesti valitulle puolelle potilaista lähetettiin kysely ja tähän vastanneilta kerättiin tiedot hoitokäynneistä ja lääkityksistä, mikä mahdollisti rekisteripohjaisten ja potilaiden raportoimien tietojen yhdistelyn. IBDt aiheuttavat merkittäviä kustannuksia kaikilla tarkastelluilla osa-alueilla, mukaan lukien terveydenhuollon palvelut, lääkehoidot ja tuottavuuden menetykset. Vaikka pieni osa potilaista aiheutti erityisen suuria kustannuksia, taloudellinen taakka jakautui laajasti koko potilasjoukolle. Tutkimus osoitti, että IBDt aiheuttavat merkittäviä suoria ja epäsuoria kustan-nuksia. Rekisteri- ja kyselyaineistojen yhdistäminen mahdollisti monipuolisen kus-tannuanalyysin ja tulokset voivat tukea tulevia kustannusvaikuttavuustutkimuksia sekä terveyspoliittista päätöksentekoa. - Ladataan...Long-term decarbonization pathways for Cuba’s electricity sector: a scenario-based analysis to 2050Casals Cunill; Ernesto Carlos; Masip Rodríguez; Carlos Alberto; Peña Pupo, Leonardo; Lora; Electo Eduardo Silva; Venturini, Osvaldo José; Adeoye, Olasunkanmi Opelowa; Jaén, René Lesme (Elsevier BV)
The Republic of Cuba faces a critical energy trilemma characterized by severe reliance on imported fossil fuels and an obsolete electricity generation infrastructure. Addressing this challenge, this study evaluates long-term decarbonization pathways exclusively for Cuba’s electricity sector from 2024 to 2050 using the Low Emissions Analysis Platform (LEAP). To improve methodological transparency, LEAP was configured using 2024 as the base year, with demand projections, generation capacity expansion, storage deployment, fuel-price assumptions, technology costs, and emissions factors represented across three scenarios. The assessment formally defines three structural frameworks: a policy-continuity baseline based on current governmental targets, a flexibility-oriented decarbonization pathway, and a 100 % renewable electricity scenario. Results indicate that while the policy-continuity scenario achieves a 35 % renewable generation share, its reliance on a conventional thermal baseload triggers a late-term emissions rebound, peaking at 12.82 million metric tons of CO2-eq by mid-century. Conversely, the flexibility-oriented pathway appears to be the most cost-effective option. By capping thermal capacity at 1,500 MW and deploying large-scale energy storage, it reduces emissions by 67 % to 4.21 million metric tons of CO2-eq and lowers annual production costs by approximately 200 million USD. Furthermore, sensitivity analyses demonstrate this flexible architecture is highly resilient to demand fluctuations. Although the 100 % renewable pathway suggests absolute electricity-sector carbon neutrality is technically achievable, its requirement for a 6,733 MW biomass scale-up introduces major capital and land-use conflicts. Ultimately, this research indicates that deep decarbonization could be an economically advantageous strategy, necessitating a paradigm shift from traditional baseloads toward system flexibility, provided significant external financial barriers can be navigated.
- Ladataan...Temperature, Light Regimes, and Harvest Time Shape the Total Volatile Content and °Brix/Acidity Balance of Strawberry Fruit (Fragaria ananassa cv. Sonsation)Santikko, Meeri; Kelanne, Niina; Yang, Baoru; Sønsteby, Anita; Hykkerud, Anne Linn (American Chemical Society (ACS))
The sensory appeal of strawberry (Fragaria × ananassa) depends on its chemical composition, including sugars, organic acids, and aroma-active volatiles. To investigate the effects of temperature and light conditions on fruit quality, strawberry plants (cv. Sonsation) were grown at six temperature regimes (9, 12, 15, 18, 21 °C, and 21/9 °C-day/night) and four combinations of light intensities (150 and 300 μmol/m2/s) and photoperiods (12 and 24 h/day). Yield, °Brix/acidity ratio and volatile compounds were assessed. °Brix increased with light intensity and photoperiod, while higher temperatures (15–21 °C) correlated with acidity. A favorable °Brix/acidity ratio correlated with both continuous light and high light intensity, as well as low ripening temperature. Volatile content peaked at 15 °C, and declined at 9 °C, proportionally elevating acids and reducing terpenoids. The findings indicate that extended high-intensity light can optimize sweetness and aroma in cv. Sonsation, whereas low temperatures benefit the °Brix-acidity balance but may reduce volatile compound development.
- Ladataan...Cultivating the Future of Healthcare: Medical Students’ Education in Patient Safety Culture and the Importance of Shared Values and NormsAghakhani, Nader; Ewalds-Kvist, Béatrice Marianne (Negah Scientific Publisher)
- Ladataan...Controlled Debundling of Single-Walled Carbon Nanotubes (SWCNTs) by Au@Pt Nanorods Enables Mechanism-Dependent Electrochemical Sensing and Biofouling ResponseMostafiz, Bahar; Rosqvist, Emil; Mäkilä, Ermei; Sharma, Vipul; Peltola, Emilia (American Chemical Society (ACS))
Single-walled carbon nanotubes (SWCNTs) form intrinsically bundled networks due to strong intertube interactions, yet conventional debundling approaches can disrupt or chemically alter the nanotube structure. Here, Au@Pt nanorods (NRs) were progressively incorporated into SWCNT films as a nondestructive strategy to deliberately debundle the network while preserving the carbon framework and introducing Pt-rich catalytic sites. This approach was used to examine how network restructuring and metal decoration govern biofouling and electrochemical sensing. Increasing NR loading reorganized the SWCNT network into thinner strands, changed conductive pathways, and increased accessible surface features and hydrophilicity. These changes yielded analyte-dependent electrochemical responses: dopamine (DA) oxidation became more adsorption-controlled after debundling, with enhanced faradaic and capacitive currents attributed to improved interfacial accumulation at carbon-rich surfaces, whereas hydrogen peroxide (H2O2) oxidation was dominated by Pt-mediated catalysis and increased with NR loading due to higher catalytic site density. Biofouling studies with bovine serum albumin (BSA) showed that high NR contents promoted protein adsorption and suppressed electrochemical activity. Interestingly, DA oxidation was least affected on pristine SWCNT electrodes, whereas H2O2 detection benefited from intermediate NR decoration, indicating that biofouling can be mitigated by tailoring the platform to the target analyte to maintain performance after protein exposure, rather than relying on antifouling surfaces.