Väitöskirjat
Sarjat
Uusimmat aineistot
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Multi-omics analysis of early molecular mechanisms of type 1 diabetes
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1602 (Turun yliopisto, 17.12.2021)Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ... -
Label-free methods for studying protein-protein interactions
Turun yliopiston julkaisuja -Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 661 (Turun yliopisto, 17.12.2021)Proteins are the building blocks of life, and mainly perform their roles through protein-protein interactions (PPIs). Thus, PPIs are essential to the normal function of the cells and the body, and disturbances in these ... -
Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates
Turun yliopiston julkaisuja-Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 600 (Turun yliopisto, 18.12.2021)Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ... -
Diffusion-weighted and functional magnetic resonance imaging of the brain in preterm and term-born adolescents
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1598 (Turun yliopisto, 17.12.2021)Magnetic resonance imaging (MRI) is widely used in clinical and research settings in the adolescent population. Technical development has allowed the use of fine-grained methods to assess both the structural and functional ... -
ENDOMET database – A means to identify novel diagnostic and prognostic tools for endometriosis
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1598 (Turun yliopisto, 17.12.2021)Endometriosis is a common benign hormone reliant inflammatory gynecological disease that affects fertile aged women and has a considerable economic impact on healthcare systems. Symptoms include intense menstrual pain, ... -
Among friends and strangers: The influence of residential context on attitudes and deliberation on immigration
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. B: Humaniora : 566 (Turun yliopisto, 10.12.2021)This dissertation analyzes how living environment influences the majority population’s attitudes toward immigration and the way they deliberate on the issue in small groups. It examines the potential of established theories ... -
Essays on income inequality and financial incentives to work
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 82 (Turun yliopisto. Turun kauppakorkeakoulu, 17.12.2021)This dissertation is about income inequality and financial incentives to work and it aims to take part to a long-lasting discussion about the equity-efficiency trade-off. It consists of an introductory chapter and three ... -
Run-time management of many-core SoCs: A communication-centric approach
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. F: Technica - Informatica : 7 (Turun yliopisto, 17.12.2021)The single core performance hit the power and complexity limits in the beginning of this century, moving the industry towards the design of multi- and many-core system-on-chips (SoCs). The on-chip communication between the ... -
Supporting pupils’ mental health in schools. Teaching staff’s and school nurses’ perceptions and the suitability of a webbased support system for pupils
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1594 (Turun yliopisto, 10.12.2021)School is an essential part of pupils’ lives, and teaching staff and school nurses have an important role in supporting pupils’ mental health. The aim of this study was to enhance knowledge related to supporting pupils’ ... -
Extended vulnerability in customer entities: A multi-actor perspective on secondary customers’ needs and experiences
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 83 (Turun yliopisto. Turun kauppakorkeakoulu, 10.12.2021)Family members are often actively involved and are essentially affected by services that are directed at their close others, especially if those close others are experiencing vulnerabilities. This phenomenon concerns all ... -
Mechanisms in health and socioeconomic wellbeing – The role of parental resources, early-life experiences, and their accumulation
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. B: Humaniora : 567 (Turun yliopisto, 10.12.2021)Wellbeing is one of the most studied topics in social sciences. Previous empirical findings suggest that particularly severe, repeated, or multiple negative exposures threaten wellbeing. Social scientific research on ... -
Particle observations in near-earth space: Design and verification of particle instruments for CubeSat experiments
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 658 (Turun yliopisto, 15.12.2021)This doctoral thesis presents the design, simulation, and calibration of two instruments developed to study energetic charged particles in low-Earth orbit. The near-Earth energetic charged particle populations include ... -
Photoluminescence quenchers in drug discovery
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 659 (Turun yliopisto, 03.12.2021)During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ... -
Housing policy in retrenchment: Constructing housing policy in times of change
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser B: Humaniora : 565 (Turun yliopisto, 17.12.2021)This dissertation examines housing policy change from a social constructionist perspective. Two processes of housing policy change are analysed together with comparative research on European housing policies. This dissertation ... -
Electrocardiographic changes in hypertension
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1588 (Turun yliopisto, 03.12.2021)The resting electrocardiogram (ECG) is a recommended procedure for the routine assessment of every hypertensive patient to detect electrocardiographic left ventricular hypertrophy (ECG-LVH), a potent cardiovascular risk ... -
Changes in mental health symptoms, bullying involvement, loneliness and service use among Finnish-speaking children aged 8-9 years over a 24-year period : A population-based study
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1590 (Turun yliopisto, 03.12.2021)ABSTRACT Cross-sectional studies, which have been collected using similar study design and measures at different time points can provide important and reliable information on changes in children’s mental health and ... -
Quantitative magnetic resonance imaging and high-intensity focused ultrasound treatment of uterine fibroids
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1953 (Turun yliopisto, 17.12.2021)Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment is an emerging non-invasive treatment method in which the targeted tissue is heated by high-intensity ultrasound causing coagulative necrosis. ... -
Välittävä kasvatus ja opetus peruskoulun yhdeksäsluokkalaisten kokemana
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. B: Humaniora : 564 (Turun yliopisto, 03.12.2021)Välittäminen nähdään ihmisen perustarpeena. Tarvitsemme heitä, jotka välittävät samoin kuin heitä, joista välitämme. Kun puhumme välittämisestä koulussa, puhumme paljolti opettajan välittävästä asenteesta oppilaita tai ... -
Historical appraisal analysis: evaluation of the book in sixteenth-century England
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. B: Humaniora : 562 (Turun yliopisto, 04.12.2021)This dissertation is a study of the evaluation of the book in the English Renaissance. The purpose of the study is to find out what a good book was like in sixteenth-century England, what personal and societal attitudes ... -
Role of cancerous inhibitor of protein phosphatase 2A in the regulation of T-cell response
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1591 (Turun yliopisto, 03.12.2021)T helper (Th) cell subsets with distinct functions are a critical component of the adaptive immune system. Th17 cells secrete interleukin 17 (IL-17) and provide host defense against pathogens. However, dysregulated Th17 ...
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