Viimeksi syötetyt Väitöskirjat

Aineistot 1-20 / 2295

    • Bioactive compounds in oats and gut health 

      Laito, Salla
      Doctoral Theses in Food Sciences at The University of Turku : 85 (Turun yliopisto, 04.02.2022)
      Recently, the nutritional advantages of oats have been acknowledged worldwide and several novel oat-based products have entered the market. Health claims on the cholesterol- and postprandial glycemia-lowering effects of ...

    • Enhanced label-free discovery proteomics through improved data analysis and knowledge enrichment 

      Välikangas, Tommi
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. F: Technica - Informatica : 8 (Turun yliopisto, 11.02.2022)
      Mass spectrometry (MS)-based proteomics has evolved into an important tool applied in fundamental biological research as well as biomedicine and medical research. The rapid developments of technology have required the ...

    • The construct of the ethical activity profile of nurse managers – effectiveness of the Ethics Quarter e-learning intervention 

      Laukkanen, Laura
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1605 (Turun yliopisto, 04.02.2022)
      Nurse managers’ ethical activities have a positive impact on personnel, the quality of patient care and overall organizational success. The aim of this two-phase study was to create the theoretical construct of the ethical ...

    • Hormone replacement therapy among Finnish menopausal women around millennium with special attention on the psychosocial background 

      Jalava-Broman, Jaana
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1599 (Turun yliopisto, 28.01.2022)
      Women today can live up to half of their lives postmenopausal. That is why the treatment of climacteric symptoms has become increasingly important. Estrogen effectively alleviates climacteric symptoms and thus improves the ...

    • Machine learning and computational methods to identify molecular and clinical markers for complex diseases – case studies in cancer and obesity 

      Seyednasrollah, Fatemeh
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Mathematica : 663 (Turun yliopisto, 04.02.2022)
      In biomedical research, applied machine learning and bioinformatics are the essential disciplines heavily involved in translating data-driven findings into medical practice. This task is especially accomplished by developing ...

    • Optimizing text mining methods for improving biomedical natural language processing 

      Mehryary, Farrokh
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. F: Technica - Informatica : 9 (Turun yliopisto, 04.02.2022)
      The overwhelming amount and the increasing rate of publication in the biomedical domain make it difficult for life sciences researchers to acquire and maintain all information that is necessary for their research. Pubmed ...

    • Novel prognostic factors for advanced melanoma and localized renal cell carcinoma 

      Mattila, Kalle E.
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1607 (Turun yliopisto, 28.01.2022)
      This study aimed to evaluate prognostic and predictive factors in melanoma and renal cell carcinoma to tailor optimal treatment and follow-up for cancer patients. Chemotherapy was the standard treatment for advanced ...

    • Metabolic pathway engineering of actinomycetes for novel antibiotics discovery 

      Baral, Bikash
      Turun yliopiston julkaisuja-Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 662 (Turun yliopisto, 21.01.2022)
      Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...

    • Is substance use of any substance? Study on substance use and mental health on Russian, Somali and Kurdish origin populations in Finland 

      Salama, Essi
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1601 (Turun yliopisto, 04.02.2022)
      To date, our knowledge on substance use in migrated populations in their host countries is scarce. In addition, associations between discrimination and substance use have been rarely investigated in the European context. The ...

    • Essays on labour market policy evaluation 

      Vehkasalo, Ville
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 85 (Turun yliopisto. Turun kauppakorkeakoulu, 28.01.2022)
      This thesis presents three previously published case studies and a new summary article, with the overall aim of improving our understanding of the use of natural experiments in studying causal relationships in social ...

    • Data-independent acquisition mass spectrometry for human gut microbiota metaproteome analysis 

      Pietilä, Sami
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1603 (Turun yliopisto, 13.01.2022)
      Human digestive tract microbiota is a diverse community of microorganisms having complex interactions between microbes and the human host. Observing the functions carried out by microbes is essential for gaining understanding ...

    • The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response 

      Kortesluoma, Susanna
      Turun yliopiston julkaisua - Annaels Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1606 (Turun yliopisto, 21.01.2022)
      The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...

    • Temporal trends and outcomes in aortic and mitral valve surgery in Finland 

      Myllykangas, Monna
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1604 (Turun yliopisto, 21.01.2022)
      Aortic valve surgery is the most common type of heart valve surgery in western countries. The main causes for aortic valve surgery are aortic valve stenosis and regurgitation. Mitral valve regurgitation is the most common ...

    • Säveltäjä-klarinetisti Bernhard Crusellin ammatillinen toiminta ja vuorovaikutus Ruotsissa 1795–1833 

      Palkisto, Janne
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser B: Humaniora : 568 (Turun yliopisto, 15.01.2022)
      Tämä kulttuurihistorian alaan kuuluva väitöskirja tutkii Uudessakaupungissa syntyneen säveltäjä-klarinetisti Bernhard Crusellin (1775–1838) ammatillista toimintaa ja vuorovaikutusta Ruotsissa vuodesta 1795 vuoteen 1833. ...

    • Novel targets for diagnostics and treatment of malignant lymphomas – special reference to histological subtypes and epidemiology 

      Juntikka, Tiina
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1592 (Turun yliopisto, 14.01.2022)
      Malignant lymphomas are currently classified as “mature B-cell neoplasms” and “mature T- and NK-cell neoplasms” (previously known as non-Hodgkin lymphomas) and Hodgkin lymphomas with over 60 subsequent subtypes. Specific ...

    • Individuals’ usage of smoking cessation online health communities 

      Li, Chenglong
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 84 (Turun yliopisto. Turun kauppakorkeakoulu, 14.01.2022)
      Smoking is still a significant threat to human health. To reduce the prevalence of smoking, the World Health Organization (WHO) has highlighted the importance of offering help to quit tobacco use. Recently, smoking cessation ...

    • Dry bonding: New perspectives for collagen hybridization 

      Stape, Thiago Henrique Scarabello
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1600 (Turun yliopisto, 17.12.2021)
      Advancements in dental adhesive technology have revolutionized dental treatments, invariably increasing the number and indications of restorative treatment options. Considering current techniques to bond to tooth tissue, ...

    • Multi-omics analysis of early molecular mechanisms of type 1 diabetes 

      Laajala, Essi
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1602 (Turun yliopisto, 17.12.2021)
      Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ...

    • Label-free methods for studying protein-protein interactions 

      Valtonen, Salla
      Turun yliopiston julkaisuja -Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 661 (Turun yliopisto, 17.12.2021)
      Proteins are the building blocks of life, and mainly perform their roles through protein-protein interactions (PPIs). Thus, PPIs are essential to the normal function of the cells and the body, and disturbances in these ...

    • Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates 

      Rosenqvist, Petja
      Turun yliopiston julkaisuja-Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 600 (Turun yliopisto, 18.12.2021)
      Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ...