SALIVARY AND SERUM MARKERS OF ANGIOGENESIS IN PERIODONTITIS IN RELATION TO SMOKING
Kasurinen, Akseli; Norvio, Susanna (2019-04-25)
25.04.2019
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
Julkaisun pysyvä osoite on:
http://urn.fi/URN:NBN:fi-fe2019051315307
http://urn.fi/URN:NBN:fi-fe2019051315307
Tiivistelmä
Angiogenesis is essential in maintenance of periodontal homeostasis, and it is regulated by growth factors and cytokines, including basic fibroblast growth factor (b-FGF), platelet and endothelial cell adhesion molecule (PECAM-1), endoglin, and vascular endothelial growth factor (VEGF). In this study we examined the relation of smoking and periodontitis to salivary and serum b-FGF, PECAM-1, endoglin, and VEGF concentrations.
Full-mouth periodontal status together with unstimulated whole saliva and serum samples were collected from 78 individuals who consisted of 40 periodontitis patients (20 smokers and 20 non-smokers), and 38 periodontally healthy controls (20 smokers and 18 non-smokers). The Luminex®-xMAP™ technique was used to analyze b-FGF, PECAM-1, endoglin and VEGF concentrations in saliva and serum. Concentrations of VEGF (p<0.001), b-FGF(p<0.001), PECAM-1 (p<0.001), and endoglin (p=0.004) in saliva, and that of VEGF (p=0.014) in serum, were higher in periodontitis patients than in controls. Endoglin concentrations in serum were elevated in smokers in comparison to non-smokers (p=0.017). After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF (OR:2.061 95% CI:1.394-3.107, p<0,001), VEGF (OR:1.002, 95% CI:1.001-1.003, p<0,001), and PECAM-1 (OR:1.001, 95% CI:1.001-1.002, p<0,001).
Taken together, salivary concentrations of VEGF, PECAM-1, and b-FGF associate with periodontitis, while smoking has no effect on this association. Serum concentration of endoglin is prone to smoking.
Full-mouth periodontal status together with unstimulated whole saliva and serum samples were collected from 78 individuals who consisted of 40 periodontitis patients (20 smokers and 20 non-smokers), and 38 periodontally healthy controls (20 smokers and 18 non-smokers). The Luminex®-xMAP™ technique was used to analyze b-FGF, PECAM-1, endoglin and VEGF concentrations in saliva and serum. Concentrations of VEGF (p<0.001), b-FGF(p<0.001), PECAM-1 (p<0.001), and endoglin (p=0.004) in saliva, and that of VEGF (p=0.014) in serum, were higher in periodontitis patients than in controls. Endoglin concentrations in serum were elevated in smokers in comparison to non-smokers (p=0.017). After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF (OR:2.061 95% CI:1.394-3.107, p<0,001), VEGF (OR:1.002, 95% CI:1.001-1.003, p<0,001), and PECAM-1 (OR:1.001, 95% CI:1.001-1.002, p<0,001).
Taken together, salivary concentrations of VEGF, PECAM-1, and b-FGF associate with periodontitis, while smoking has no effect on this association. Serum concentration of endoglin is prone to smoking.