Patient reported androgen driven phenotypes do not associate with biochemical recurrence after radical prostatectomy
Kuusento, Konsta (2020-03-04)
Patient reported androgen driven phenotypes do not associate with biochemical recurrence after radical prostatectomy
(04.03.2020)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe202003128049
https://urn.fi/URN:NBN:fi-fe202003128049
Tiivistelmä
Introduction
Prostate cancer is the most common type of cancer among men in developed countries. The most critical risk factors are age, ethnicity and body mass index. Androgen driven phenotypical features, such as acne vulgaris, male pattern baldness and digit length, have been shown to be associated with increased risk of prostate cancer. The possible association between these features and the risk of biochemical recurrence has not been studied before. This study aimed to search for possible associations between these self-reported phenotypical features and the aggressiveness and the occurrence of biochemical recurrence of prostate cancer.
Materials and Methods
The study cohort (n=628) consisted of men who had undergone a radical prostatectomy between 2013 and 2019 in Turku University Hospital. The subjects were issued a questionnaire in which information about the phenotypical features was surveyed. Pre-, peri- and post-operative data of the subjects was collected. The main clinical variables in this study were preoperative PSA, pathological Gleason score and pathological T-stage. Also, a possible biochemical recurrence was plotted in post-operative controls. To study the occurrence of biochemical relapse (BCR) in men with different androgen associated phenotypical features, a Kaplan Meier analysis was performed.
Results
Mean age was 63 years at diagnosis. Of the 628 men studied, 54% had light or total balding, 59% had no self-reported acne at adolescence or later, and 77% had index finger shorter than the ring finger. Androgenic alopecia (HR 0.64, 95%CI 0.31-1.31, P=0.226), low 2D:4D ratio (HR 1.45, 95%CI 0.68-3.09, P=0.334) or acne (HR 1.43, 95%CI 0.71-2.89, P=0.322) did not have an effect on the occurrence of BCR.
Conclusions
Patient reported androgen driven phenotypes do not associate with cancer aggressiveness or biochemical recurrence. Therefore, it seems that a prospective trial assessing these features is not feasible.
Prostate cancer is the most common type of cancer among men in developed countries. The most critical risk factors are age, ethnicity and body mass index. Androgen driven phenotypical features, such as acne vulgaris, male pattern baldness and digit length, have been shown to be associated with increased risk of prostate cancer. The possible association between these features and the risk of biochemical recurrence has not been studied before. This study aimed to search for possible associations between these self-reported phenotypical features and the aggressiveness and the occurrence of biochemical recurrence of prostate cancer.
Materials and Methods
The study cohort (n=628) consisted of men who had undergone a radical prostatectomy between 2013 and 2019 in Turku University Hospital. The subjects were issued a questionnaire in which information about the phenotypical features was surveyed. Pre-, peri- and post-operative data of the subjects was collected. The main clinical variables in this study were preoperative PSA, pathological Gleason score and pathological T-stage. Also, a possible biochemical recurrence was plotted in post-operative controls. To study the occurrence of biochemical relapse (BCR) in men with different androgen associated phenotypical features, a Kaplan Meier analysis was performed.
Results
Mean age was 63 years at diagnosis. Of the 628 men studied, 54% had light or total balding, 59% had no self-reported acne at adolescence or later, and 77% had index finger shorter than the ring finger. Androgenic alopecia (HR 0.64, 95%CI 0.31-1.31, P=0.226), low 2D:4D ratio (HR 1.45, 95%CI 0.68-3.09, P=0.334) or acne (HR 1.43, 95%CI 0.71-2.89, P=0.322) did not have an effect on the occurrence of BCR.
Conclusions
Patient reported androgen driven phenotypes do not associate with cancer aggressiveness or biochemical recurrence. Therefore, it seems that a prospective trial assessing these features is not feasible.