CD206 in colon cancer
Salonen, Tuomas (2020-03-17)
CD206 in colon cancer
(17.03.2020)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2020042722579
https://urn.fi/URN:NBN:fi-fe2020042722579
Tiivistelmä
The assessment of immunologic milieu in cancer tissue has proven to be a powerful factor in estimation of disease outcome. The basic idea is to characterize the presence of different immune cell types within tumor tissue. In this study the expression of macrophage mannose receptor (CD206) in colon cancer tissue was assessed. The aim of the study was to determine whether CD206 positivity possesses a prognostic role in case of colon cancer. CD206 is an endocytic scavenging receptor which is characteristic especially for regulatory macrophages.
The data was based on formalin fixed paraffin embedded colon cancer tissue sections in tumor micro array (TMA) form. The data consisted of tissue samples of 214 cancer patients all together. The samples were stained immunohistochemically with immunoperoxidase method and scanned into digital form. Thereafter, the number of CD206 positive macrophages was determined manually from the images. The amount of CD206 positive cells was statistically compared to numerous clinico-pathological parameters and patient survival data. The macrophages of the tumor core and invasive margin were analyzed separately.
It was found that high CD206 positivity in tumor’s invasive margin positively correlated to overall patient survival (p=0.022). Moreover, an even better correlation was found within the group of proximal colon tumors. The multivariate analysis showed that CD206 has an independent prognostic value compared to other clinico-pathological parameters. The conclusion is that high number of CD206 positive macrophages in the invasive margin of colon cancer is a promising new predictor for a more favorable disease outcome especially in case of proximal tumors.
The data was based on formalin fixed paraffin embedded colon cancer tissue sections in tumor micro array (TMA) form. The data consisted of tissue samples of 214 cancer patients all together. The samples were stained immunohistochemically with immunoperoxidase method and scanned into digital form. Thereafter, the number of CD206 positive macrophages was determined manually from the images. The amount of CD206 positive cells was statistically compared to numerous clinico-pathological parameters and patient survival data. The macrophages of the tumor core and invasive margin were analyzed separately.
It was found that high CD206 positivity in tumor’s invasive margin positively correlated to overall patient survival (p=0.022). Moreover, an even better correlation was found within the group of proximal colon tumors. The multivariate analysis showed that CD206 has an independent prognostic value compared to other clinico-pathological parameters. The conclusion is that high number of CD206 positive macrophages in the invasive margin of colon cancer is a promising new predictor for a more favorable disease outcome especially in case of proximal tumors.