Association between infant gut microbiota composition and temperament
Huovinen, Venla (2021-09-13)
Association between infant gut microbiota composition and temperament
Huovinen, Venla
(13.09.2021)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021092346985
https://urn.fi/URN:NBN:fi-fe2021092346985
Tiivistelmä
Previous studies have shown an association between gut microbiota composition and neurodevelopment and eventually behaviour. This association has been studied further by investigating the association between early gut microbiota composition and child temperament. However, there is still scarce research on at which points of infancy the association is observed and what the underlying mechanisms are (Aatsinki et al., 2019). More knowledge on the association between gut microbiota composition and temperament is needed. The aim of this study was to examine how early gut microbiota composition is associated with child temperament across the first year of life. More specifically, we were interested whether the gut microbiota diversity, overall composition and genera abundances were associated with observed (8 mo) and reported (12 mo) child negative reactivity and fear reactivity. Further, we were interested in possible sex-specific differences in these associations. Participants of this study (n = 330) belong to the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was obtained collecting stool samples at the child age 2.5 months (and sequenced with 16S Illumina MiSeq platform). Negative reactivity and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at the child’s age of 8 months and the maternal reports of Infant Behaviour Questionnaire-Revised Short Form (IBQ-R) at the child’s age of 12 months. We found sex-specific associations between alpha diversity and reported fear reactivity as well as observed negative reactivity. The overall composition, i.e. beta diversity, was associated with reported and observed negative reactivity for boys. Finally, several genera were associated with temperament measurements with most prominent negative associations between genus [Ruminococcus] gnavus group and reported negative reactivity and fear and positive associations between genus Clostridium sensu stricto 1 and observed fear reactivity. This study adds to the growing literature on infant gut microbiota and temperament and highlights the possible sex-specific effects in this relationship. Future research should employ longitudinal follow-ups through several measurement points of temperament and gut microbiota to further assess the complexity and trajectories of the phenomena.