Hae
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Dose-area product ratio in external small-beam radiotherapy: beam shape, size and energy dependencies in clinical photon beams
In small-field radiotherapy (RT), a significant challenge is to define the amount of radiation dose absorbed in the patient where the quality of the beam has to be measured with high accuracy. The properties of a proposed ...
Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study
<p>Background: Cardiometabolic health among adult offspring of hypertensive disorders of pregnancy (HDP) is relatively unknown. We hypothesized that offspring of HDP would have abnormalities in the retinal microvasculature ...
Means of reaching successful antenatal transfers to level 3 hospitals in cases of threatened very preterm deliveries: a national survey
<div><b>Introduction</b> Centralization of very preterm deliveries to level 3 hospitals is recommended to improve infant survival and prevent brain injury. We studied the clinical practices of centralization from level 2 ...
Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis
Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different infections and single nucleotide polymorphisms ...
Sleep during menopausal transition: a 10-year follow-up (vol 40, pg , 2021)
(2021-12-01)
<div><div><div>This is a correction to: Sleep, Volume 44, Issue 6, June 2021, zsaa283, <a href="https://doi.org/10.1093/sleep/zsaa283">https://doi.org/10.1093/sleep/zsaa283</a> </div></div></div>...
Immediate verbal recall and familial dementia risk: population-based study of over 4000 twins
To investigate the effect of familial risk for dementia on verbal learning by comparing cognitively healthy twins who had demented co-twins with cognitively healthy twins who had cognitively healthy co-twins.\n4367 twins ...
Variants associated with HHIP expression have sexdifferential effects on lung function
<p><strong>Background:</strong> Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.<br><strong>Methods:</strong> We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium.<br><strong>Results:</strong> Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10<sup>-8</sup>) interactions with sex on lung function, and 21 showed suggestive interactions (P<1x10<sup>-6</sup>). The strongest signal, from rs7697189 (chr4:145436894) on forced expiratory volume in 1 second (FEV<sub>1</sub>) (P=3.15x10<sup>-15</sup>), was replicated (P=0.016) in SpiroMeta. The C allele increased FEV<sub>1</sub> more in males (untransformed FEV<sub>1</sub> β=0.028 [SE 0.0022] litres) than females (β=0.009 [SE 0.0014] litres), and this effect was not accounted for by differential effects on height, smoking or pubertal age. rs7697189 resides upstream of the hedgehog-interacting protein (HHIP) gene and was previously associated with lung function and HHIP lung expression. We found HHIP expression was significantly different between the sexes (P=6.90x10-6), but we could not detect sex differential effects of rs7697189 on expression.<br><strong>Conclusions:</strong> We identified a novel genotype-by-sex interaction at a putative enhancer region upstream of the HHIP gene. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases in both sexes.</p>...
Infection with possible novel parapoxvirus in horse, Finland, 2013
<p>A horse in Finland exhibited generalized granulomatous inflammation and severe proliferative dermatitis. After euthanization, we detected poxvirus DNA from a skin lesion sample. The virus sequence grouped with parapoxviruses, ...
Insulin Resistance Predicts Cognitive Decline: An 11-Year Follow-up of a Nationally Representative Adult Population Sample
OBJECTIVEThe aim of this study was to examine whether insulin resistance, assessed by HOMA of insulin resistance (HOMA-IR), is an independent predictor of cognitive decline.RESEARCH DESIGN AND METHODSThe roles of HOMA-IR, ...
Structural validity of the Boston Carpal Tunnel Questionnaire and its short version, the 6-Item CTS symptoms scale: a Rasch analysis one year after surgery
Background The Boston Carpal Tunnel Questionnaire (BCTQ) and its shorter version, the Six-Item Carpal Tunnel Symptoms Scale (CTS-6), are widely used for assessing function and/or symptoms in patients with carpal tunnel ...