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An unbiased in vitro screen for activating epidermal growth factor receptor mutations
Cancer tissues harbor thousands of mutations, and a given oncogene may
be mutated at hundreds of sites. Yet, only a few of these mutations have
been functionally tested. Here, we describe an unbiased platform for
the ...
Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor
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Pim-1 is an oncogenic serine/threonine kinase with poorly defined function in epithelial cancers. In this study, we determined 1) associations of Pim-1 expression with clinicopathological parameters including ...
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos
Tyrosine kinase inhibitors are widely used in the clinic, but limited information is available about their toxicity in developing organisms. Here, we tested the effect of tyrosine kinase inhibitors targeting the ErbB ...