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Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling
Cell-extracellular matrix (ECM) adhesion is a fundamental requirement for multicellular existence due to roles in positioning, proliferation and differentiation. Phosphorylation plays a major role in adhesion signalling; ...
A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting
Integrin activation, which is regulated by allosteric changes in receptor conformation, enables cellular responses to the chemical, mechanical and topological features of the extracellular microenvironment. A global view ...