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A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments
Background: Chromatin immunoprecipitation coupled with massively parallel sequencing (ChIPseq)<br />is increasingly being applied to study transcriptional regulation on a genome-wide scale. While<br />numerous algorithms ...
Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation
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We used stable isotope labeling with 4-plex iTRAQ (isobaric tags for relative and absolute quantification) reagents and LC-MS/MS to investigate proteomic changes in the nucleus of activated human CD4(+) cells during ...