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Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes
<p>Lymph nodes (LNs) filter lymph to mount effective immune responses. Small soluble lymph-borne molecules from the periphery enter the draining LNs via a reticular conduit system. Intact antibodies and other larger ...
Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer
Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of ...
Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
<p><strong>Background: </strong>Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to ...
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
<h4>OBJECTIVE: </h4><p>Primary
sclerosing cholangitis (PSC) is the classical hepatobiliary
manifestation of IBD. This clinical association is linked pathologically
to the recruitment of mucosal T cells to the liver, ...
Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice
Clever-1, encoded by the Stab1 gene, is a scavenger and leukocyte trafficking receptor expressed by subsets of vascular and lymphatic endothelial cells and immunosuppressive macrophages. Monocyte Clever-1 also modulates T ...
Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes
Whereas adenosine 5'-triphosphate (ATP) is the major energy source in cells, extracellular ATP (eATP) released from activated/damaged cells is widely thought to represent a potent damage-associated molecular pattern that ...
The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects
<p>Background:</p><p>Surgery and diseases modify inflammatory responses and the immune system. Anesthetic agents also have effects on the human immune system but the responses they induce may be altered or masked by the ...