Viimeksi syötetyt 3. UTUCris-artikkelit
Aineistot 10321-10340 / 19207
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C-SPADE: a web-tool for interactive analysis and visualization of drug screening experiments through compound-specific bioactivity dendrograms
The advent of polypharmacology paradigm in drug discovery calls for novel chemoinformatic tools for analyzing compounds' multi-targeting activities. Such tools should provide an intuitive representation of the chemical ... -
Detecting Non-Markovianity of Quantum Evolution via Spectra of Dynamical Maps
We provide an analysis on non-Markovian quantum evolution based on the spectral properties of dynamical maps. We introduce the dynamical analog of entanglement witness to detect non-Markovianity and we illustrate its ... -
Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
Whooping cough is caused by Bordetella pertussis that releases pertussis toxin (PT) which comprises enzyme A-subunit PTS1 and binding/transport B-subunit. After receptor-mediated endocytosis, PT reaches the endoplasmic ... -
Observation of New Properties of Secondary Cosmic Rays Lithium, Beryllium, and Boron by the Alpha Magnetic Spectrometer on the International Space Station
We report on the observation of new properties of secondary cosmic rays Li, Be, and B measured in the rigidity (momentum per unit charge) range 1.9 GV to 3.3 TV with a total of 5.4 x 10(6) nuclei collected by AMS during ... -
Cultivation and Genomics Prove Long-Term Colonization of Donor's Bifidobacteria in Recurrent Clostridioides difficile Patients Treated With Fecal Microbiota Transplantation
Fecal microbiota transplantation (FMT) is an effective treatment for recurrentClostridioides difficileinfection (rCDI) and it's also considered for treating other indications. Metagenomic studies have indicated that commensal ... -
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture
We describe an emerging initiative - the 'Functional Annotation of All Salmonid Genomes' (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ... -
Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
<div>Purpose: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral ... -
Impact of JNK and Its Substrates on Dendritic Spine Morphology
The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins. JNK1 also phosphorylates dendritic spine ... -
Ruoka-allergiat aikuisilla
Ruoka-allergia ilmenee toistuvasti samaan ruokaan liittyvänä iho-, limakalvo-, hengitystie- tai suolisto-oireilun. Pelkän suolisto-oireen syy on useammin muu kuin allergia. Koivun siitepölyallergiaan liittyvät lievät suun ... -
Small Force, Big Impact: Next Generation Organ-on-a-Chip Systems Incorporating Biomechanical Cues
Mechanobiology-on-a-chip is a growing field focusing on how mechanical inputs modulate physico-chemical output in microphysiological systems. It is well known that biomechanical cues trigger a variety of molecular events ... -
Interlobate esker architecture and related hydrogeological features derived from a combination of high-resolution reflection seismics and refraction tomography, Virttaankangas, southwest Finland
<p>A novel high-resolution (2–4 m source and receiver spacing) reflection and refraction seismic survey was carried out for aquifer characterization and to confirm the existing depositional model of the interlobate ... -
Combined effect of salinity and temperature on copepod reproduction and oxidative stress in brackish-water environment
<p>Climate-induced warming and increased river inflows are forcing the Baltic Sea to radical changes in the near future; organisms living in this brackish-water ecosystem are already experiencing osmotic stress, which, ... -
Comparing the generalized Kadanoff-Baym ansatz with the full Kadanoff-Baym equations for an excitonic insulator out of equilibrium
We investigate out-of-equilibrium dynamics in an excitonic insulator (EI) with a finite-momentum pairing perturbed by a laser-pulse excitation and a sudden coupling to fermionic baths. The transient dynamics of the excitonic ... -
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2R alpha, c-myc, and pim-1 genes in human T cells
Interferon-alpha (IFN-alpha) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions. There is increasing evidence that IFN-alpha has an important role in T-cell biology. We have ... -
Reductive Amination of Ketones with Benzylamine Over Gold Supported on Different Oxides
<p>Reductive amination of cyclohexanone with benzylamine was investigated at 100 °C under 30 bar hydrogen in toluene with five different gold catalysts prepared by deposition–precipitation method and supported on TiO2, ... -
Work ability and physical fitness among aging workers: the Finnish Retirement and Aging Study
<p>Background With advancing age, physical capacity gradually decreases which may lead to decreased work ability, if the physical work requirements remain the same. Examination of the importance of physical fitness for ... -
Wild strawberry shows genetic variation in tolerance but not resistance to a generalist herbivore
Plants' defenses against herbivores usually include both resistance and tolerance mechanisms. Their deployment has predominantly been studied in either single-plant genotypes or multiple genotypes exposed to single herbivores. ...
