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Effects of 6 weeks of treatment with dapagliflozin, a sodium- glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes: A randomized, placebo-controlled, exploratory study
<p><strong>Aim: </strong>To explore the early effects of dapagliflozin on myocardial function and metabolism in patients with type 2 diabetes without heart failure.</p><p><strong>Materials and methods: </strong>Patients ... -
Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study
<p><i>Background</i>: Leukotrienes are pro-inflammatory vasoactive lipid mediators implicated in the pathophysiology of atherosclerotic cardiovascular disease. We studied the effect of the 5-lipoxygenase-activating protein ... -
SGLT2 inhibition reduces myocardial oxygen consumption
<p><em>Aims/hypothesis:</em> SGLT2 inhibition is associated with a reduced risk of cardiac disease that is still largely unexplained. According to one hypothesis, improved myocardial energetics may explain the cardioprotective ...
