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    • Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine 

      Palani Senthil; Miner Maxwell W. G.; Virta Jenni; Liljenbäck Heidi; Eskola Olli; Örd Tiit; Ravindran Aarthi; Kaikkonen Mnna U.; Knuuti Juhani; Li Xiang-Guo; Saraste Antti; Roivainen Anne
      Increased glutamine metabolism by macrophages is associated with development of atherosclerotic lesions. Positron emission tomography/computed tomography (PET/CT) with a glutamine analog (2S,4R)-4-F-18-fluoroglutamine ...

    • Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease 

      Linna-Kuosmanen Suvi; Schmauch Eloi; Galani Kyriakitsa; Ojanen Johannes; Boix Carles A.; Örd Tiit; Toropainen Anu; Singha Prosanta K.; Moreau Pierre R.; Harju Kristiina; Blazeski Adriana; Segerstolpe Åsa; Lahtinen Veikko; Hou Lei; Kang Kai; Meibalan Elamaran; Agudelo Leandro Z.; Kokki Hannu; Halonen Jari; Jalkanen Juho; Gunn Jarmo; MacRae Calum A.; Hollmén Maija; Hartikainen Juha E.K.; Kaikkonen Minna U.; García-Cardeña Guillermo; Tavi Pasi; Kiviniemi Tuomas; Kellis Manolis
      <p>Cardiovascular disease plays a central role in the electrical and structural remodeling of the right atrium, predisposing to arrhythmias, heart failure, and sudden death. Here, we dissect with single-nuclei RNA sequencing ...