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Dose-area product ratio in external small-beam radiotherapy: beam shape, size and energy dependencies in clinical photon beams
In small-field radiotherapy (RT), a significant challenge is to define the amount of radiation dose absorbed in the patient where the quality of the beam has to be measured with high accuracy. The properties of a proposed ...
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart
Rationale:Cardiac ECM (extracellular matrix) comprises a dynamic molecular network providing structural support to heart tissue function. Understanding the impact of ECM remodeling on cardiac cells during heart failure ...
Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis
Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different infections and single nucleotide polymorphisms ...
The ERK-1 function is required for HSV-1-mediated G1/S progression in HEP-2 cells and contributes to virus growth
The herpes simplex virus 1 is able to readdress different cellular pathways including cell cycle to facilitate its replication and spread. During infection, the progression of the cell cycle from G1 to S phase makes the ...
Polygenic Hyperlipidemias and Coronary Artery Disease Risk
Background:<div>Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what ...
A novel processing-based classification and conventional food grouping to estimate milk product consumption in Finnish children
<p>As more information is needed about the health aspects of milk processing; we classified milk products based on their homogenisation and heat-treatment history in the following inclusive classes: (i) homogenised, (ii) ...
Reversibility of myocardial metabolism and remodelling in morbidly obese patients 6 months after bariatric surgery
<h3>Abstract</h3><div><h4>AIMS: </h4><p>To study myocardial substrate uptake, structure and function, before and after bariatric surgery, to clarify the interaction between myocardial metabolism and cardiac remodelling in ...
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show ...