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An assessment of prevalence of Type 1 CFI rare variants in European AMD, and why lack of broader genetic data hinders development of new treatments and healthcare access
<p><strong>Purpose</strong><br>Advanced age-related macular degeneration (AAMD) risk is associated with rare complement Factor I (FI) genetic variants associated with low FI protein levels (termed ‘Type 1’), but it is ...
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the clathrin- and dynamin-independent endocytic ...
Increased incidence of melanoma in children and adolescents in Finland in 1990-2014: nationwide re-evaluation of histopathological characteristics
<p><br></p><p>Background</p><p>Changes in the incidence of melanoma in children and adolescents have been reported in Europe and in the USA in the recent decades.</p><p>Aims</p><p>The aim of this study was to examine the ...