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AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses
<p>Therapeutic angiogenesis induced by gene therapy is a promising approach to treat patients suffering from severe coronary artery disease. In small experimental animals, adeno-associated viruses (AAVs) have shown good ...
First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1
Sialic acid-binding immunoglubulin-like lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1 (VAP-1). A gallium 68-labeled peptide of Siglec-9, <sup>68</sup>Ga-DOTA-Siglec-9, holds promise as a novel PET tracer ...
Association between [Ga-68]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model
Radiolabeled RGD peptides targeting expression of alpha(v)beta(3) integrin have been applied to in vivo imaging of angiogenesis. However, there is a need for more information on the quantitative relationships between RGD ...
Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine
Increased glutamine metabolism by macrophages is associated with development of atherosclerotic lesions. Positron emission tomography/computed tomography (PET/CT) with a glutamine analog (2S,4R)-4-F-18-fluoroglutamine ...
Atherosclerotic plaque characteristics on quantitative coronary computed tomography angiography associated with ischemia on positron emission tomography in diabetic patients
<p>Patients with diabetes mellitus (DM) may show diffuse coronary artery atherosclerosis on coronary computed tomography angiography (CTA). The present study aimed at quantification of atherosclerotic plaque with CTA and ...
Quantitative myocardial perfusion response to adenosine and regadenoson in patients with suspected coronary artery disease
Background The aim of the present study was to compare the quantitative flow responses of regadenoson against adenosine using cardiac O-15-water PET imaging in patients with suspected or known coronary artery disease (CAD). ...
Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis
<p>The <sup>68</sup>Gallium-labeled 1,4,7-triazacyclononane-1-glutaric acid-4,7-diacetic acid conjugated radiolabelled arginine-glycine-aspartic acid peptide ([<sup>68</sup>Ga]Ga-NODAGA-RGD) is a positron emission tomography (PET) tracer binding to cell surface receptor α<sub>v</sub>β<sub>3</sub> integrin that is upregulated during angiogenesis and inflammation. We studied whether α<sub>v</sub>β<sub>3</sub> targeting PET imaging can detect myocardial inflammation in a rat model of autoimmune myocarditis. To induce myocarditis, rats (n = 8) were immunized with porcine cardiac myosin in complete Freund's adjuvant on days 0 and 7. Control rats (n = 8) received Freund's adjuvant alone. On day 21, in vivo PET/CT imaging with [<sup>68</sup>Ga]Ga-NODAGA-RGD followed by ex vivo autoradiography and immunohistochemistry were carried out. Inflammatory lesions were detected histologically in the myocardium of 7 out of 8 immunized rats. In vivo PET images showed higher [<sup>68</sup>Ga]Ga-NODAGA-RGD accumulation in the myocardium of rats with inflammation than the non-inflamed myocardium of control rats (SUV<sub>mean</sub> 0.4 ± 0.1 vs. 0.1 ± 0.02; P = 0.00006). Ex vivo autoradiography and histology confirmed that [<sup>68</sup>Ga]Ga-NODAGA-RGD uptake co-localized with inflammatory lesions containing α<sub>v</sub>β<sub>3</sub> integrin-positive capillary-like structures. A non-specific [<sup>68</sup>Ga]Ga-DOTA-(RGE)<sub>2</sub> tracer showed 76% lower uptake than [<sup>68</sup>Ga]Ga-NODAGA-RGD in the inflamed myocardium. Our results indicate that α<sub>v</sub>β<sub>3</sub> integrin-targeting [<sup>68</sup>Ga]Ga-NODAGA-RGD is a potential PET tracer for the specific detection of active inflammatory lesions in autoimmune myocarditis.<br></p>...
Classification of ischemia from myocardial polar maps in 15 O-H 2 O cardiac perfusion imaging using a convolutional neural network
<p>We implemented a two-dimensional convolutional neural network (CNN) for classification of polar maps extracted from Carimas (Turku PET Centre, Finland) software used for myocardial perfusion analysis. 138 polar maps ...
Sex differences in coronary plaque changes assessed by serial computed tomography angiography
Long-term data on sex-differences in coronary plaque changes over time is lacking in a low-to-intermediate risk population of stable coronary artery disease (CAD). The aim of this study was to evaluate the role of sex on ...