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Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Schulze MB; Travis R; Salmi M; Zuber V; Palaniswamy S; Jalkanen S; PRACTICAL consortium; Karhunen V; Brennan P; Lehtimaki T; Raitakari O; Salomaa V; Hung RJ; Katsoulis M; Martin P; Keinanen-Kiukaanniemi S; Mannikko M; Murphy N; Ahola-Olli A; Huang J; Haycock PC; Amos CI; Jarvelin MR; Gunter MJ; Martin RM; Lewis SJ; Dossus L; Key T; Auvinen J; Platz EA; Dehghan A; Nost TH; Herzig KH; Freisling H; Yarmolinsky J; Gill D; Tsilidis KK; Bouras E; Johansson M

Background: Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to ...

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Olinto MTA; Casanueva FF; Tarqui-Mamani CB; Patel ND; Yusoff MFM; Wang NL; Lozano JE; Jiang CQ; Salomaa V; Peer N; Henriques A; Carrillo-Larco RM; Ruidavets JB; Posso AJM; Henrique RD; Shirani M; Bennett JE; Viswanathan B; Musa KI; Gonzalez AR; Avdicova M; Schmidt CO; James K; Shimizu-Furusawa H; Duboz P; Nguyen QN; Dankner R; Brenner H; Kauhanen J; Marild SB; Tulloch-Reid MK; Brito M; Tsugane S; Djalalinia S; Sabanayagam C; Bao KLN; Hamzeh B; Starc G; Jurak G; Gasull M; Boggia JG; Otero JA; Chen SH; da Silva BGC; Kriaucioniene V; Aekplakorn W; Lovrencic IL; Gorbea MB; Karki KB; Islam SMS; Guerrero R; Lukrafka JL; Kim DW; Zins M; Fujita Y; Batieha AM; Bhagyalaxmi A; Metspalu A; Ornelas R; Sparboe-Nilsen B; Banegas JR; Rahman M; Schutte AE; Giampaoli S; Gunnlaugsdottir J; Trichopoulou A; Lilly CL; Kubinova R; Zhen SQ; Woo J; Haghshenas R; Amougou N; Bebakar WMW; Noale M; de Leon AC; Milanovic SM; Sonestedt E; Ahmadizar F; Sorgjerd EP; Salonen JT; Mohammadifard N; Auvinen J; Cervantes-Loaiza M; Lingam V; Meisinger C; Pourshams A; Chudek J; Mathiesen EB; Fink G; Noto D; Torrent M; Lustigova M; Iurilli MLC; Pikhart H; Tolstrup JS; Elosua R; Allin K; Petkeviciene J; Shin DW; Boker LK; Wang YW; Baran J; van Dam RM; Rezaianzadeh A; Lappas G; Victora CG; Gomez LF; Noboa OA; Joshi P; Crampin AC; Mirrakhimov E; Owusu-Dabo E; Jha AK; Ajlouni K; Neuhauser HK; Landrove O; Chaturvedi N; Verstraeten R; Do HTP; Jokelainen JJ; Lin X; Nunes B; Maire B; Machado-Rodrigues AM; van Zutphen EM; Zoghlami N; Donfrancesco C; Ben Romdhane H; Van Herck K; Hao J; Joffres M; Trivedi A; Lee J; Laid Y; Peltonen M; Shibuya K; Tjonneland A; Sathish T; Zholdin B; Belavendra A; Mi J; Donoso SP; Kim HC; Alkerwi A; Damasceno A; Gaciong Z; Lissner L; Motta J; Frontera G; Barros MVG; Wong A; Delisle H; Simons J; Anjana RM; Ramos E; Farzadfar F; Mridha MK; Schramm S; Fuchs SC; Safiri S; Topor-Madry R; Zambon S; Olie V; Aryal KK; Chaturvedi HK; Machado-Coelho GLL; Halkjaer J; Oda E; Timmermans EJ; Gareta D; Gonzalez-Gross M; Martinez ES; Rodriguez-Perez MD; Ansari-Moghaddam A; Bata I; Panza F; Bia D; Lima-Costa MF; Tang X; Turley ML; Jacobs JM; Papandreou D; Kiechl-Kohlendorfer U; Fernandez-Berges D; Xu L; Luszczki E; Zaw KK; Salmeron D; Kratenova J; Evans A; Rubinstein A; Saramies JL; Noorbala AA; Araujo J; Pilotto L; Vasan SK; Thuesen BH; Ferrieres J; Key T; Chen ZM; Demarest S; Ndiaye NC; Modesti PA; Jarvelin MR; Grosso G; Margozzini P; Cifkova R; Wiecek A; Chiou ST; Babu BV; Punab M; Kengne AP; Gieger C; Cardoso VC; Baur LA; Lotufo PA; Acosta-Cazares B; Paccaud FM; Gomula A; De Henauw S; Mostafa A; Afsana K; Willeit P; Lehtimaki T; Manzato E; Balanova Y; Gazzinelli A; Mehrparvar AH; Dika Z; Huerta JM; Bernabe-Ortiz A; Gkiouras K; Dinc GH; Parnell WR; Doring A; Dziankowska-Zaborszczyk E; van den Born BJ; Meirhaeghe A; Yasuharu T; Iwasaki M; Zapata ME; Linneberg A; Mohamud WNW; Katz J; Bloch KV; Matsha TE; McLachlan S; Mohammad K; Jimenez RO; Younger-Coleman NO; Providencia R; Boeing H; Kavousi M; Dennison E; Al-Raddadi R; Weres A; Padez C; Bettiol H; Twig G; Paoli M; Gutzwiller F; Htike MMT; Rodriguez-Villamizar LA; Sylva RC; Solfrizzi V; Cheraghian B; Erem C; Cowan MJ; Gill TK; Marques LP; McFarlane SR; Kaaks R; Servais J; Juresa V; Jasienska G; Abdeen ZA; Maggi S; Bista B; Stessman J; Mohebi F; Ferreira HS; Grafnetter D; Barreto M; Ninomiya T; Najafi F; Goldberg M; Felix SB; Dobson AJ; Ostojic SM; Schipf S; Cisneros JZ; Pecin I; Guessous I; Nguyen ND; Lehmann N; Ghanbari A; de Wit TFR; Capuano V; AlBuhairan F; Soemantri A; Korrovits P; Yusoff AF; Wong TY; Moon JS; Barcelo A; Cottel D; Candido APC; Stavreski B; Burns C; Keinanen-Kiukaanniemi S; Ahmadi A; Vanuzzo D; Price AJ; Polasek O; O'Reilly D; Kyobutungi C; Joukar F; Berkinbayev S; Odili AN; Santos IS; Miller JC; Zhu D; Touloumi G; Schargrodsky H; Gupta R; Ferrante D; Zampelas A; Siani A; Kim J; Taylor J; Norat T; Bartosiewicz A; Hwalla N; Huybrechts I; Chan Q; Vega T; Kolsteren P; Jackson RT; Magriplis E; Oh K; Deev AD; Gupta PC; Irazola VE; Bo S; Medzioniene J; Alkandari A; Rampal S; Panda-Jonas S; Ostovar A; Giwercman A; Peters A; Chen HS; Walton J; Mohajer B; Gudmundsson EF; Fischer K; Uusitalo HMT; Zamani F; De Bacquer D; Nordestgaard BG; Tuliakova AM; Sen A; Wong-McClure RA; Huhtaniemi IT; Njelekela MA; Valvi D; Ikram MA; Rahim HFA; Sachdev HS; AlDhukair S; Van der Heyden J; Agyemang C; Schaan BD; Yaacob NA; Sharma SK; Soric M; Raitakari O; Eriksson JG; Sy RG; Bugge A; Nordendahl M; Hambleton IR; Rojas-Martinez R; Wannamethee SG; Werner B; Ariansen I; You SL; Price JF; Gonzalez-Villalpando C; Matijasevich A; Farjam M; Mikkel K; Deepa M; Marques-Vidal P; Santos LC; Shayanrad A; Lachat C; Mohamed SF; Ferreccio C; Rao SR; Wareham N; Wilsgaard T; Chien KL; Van Schoor NM; Sabbaghi H; De Ridder D; Simon M; Raj M; Piwonska A; Visvikis-Siest S; Banadinovic M; Rigo F; Escobedo-de la Pena J; Tammesoo ML; Bojesen SE; Afzal S; Sun CA; Tornaritis MJ; Grodzicki T; Roy JGR; Mostafavi SA; Singleton RK; Thinggaard M; Sarganas G; Stockl D; Chamukuttan S; Pavlyshyn H; Gunter MJ; He J; Dallongeville J; Sbaraini M; Pourfarzi F; Kannan S; Banach M; Mascarenhas LP; Howitt C; Mohammadi MR; Mondo CK; Vioque J; Wyszynska J; Saidi O; Shaw JE; Poustchi H; Bjertness MB; Mohebbi I; Dauchet L; Triantafyllou A; Guimaraes AL; Bovet P; Tzourio C; Fernandes RA; Dantoft TM; Peixoto SV; Foo LH; Bandosz P; Ekelund U; Veidebaum T; Ma J; Richter A; Palmieri L; Ferrario MM; Morgan K; Branca F; Pitakaka F; Siantar R; Hadaegh F; Balakrishna N; Salanave B; Neal WA; de Gaetano G; Sundstrom J; Cinteza E; Dushpanova A; Bursztyn M; Magliano DJ; Yan WL; Horimoto ARVR; Di Castelnuovo AF; Cheng CY; Minderico CS; Craig CL; Klakk H; Arku RE; Nishtar S; Simons LA; Velasquez-Melendez G; Eftekhar E; Zheng YF; Kiechl S; Jockel KH; Tormo MJ; Santos DA; Briceno Y; Juolevi A; Tolonen HK; Yoshihara A; Gironella G; Capkova N; Stehle P; Alarouj M; De Smedt D; Danaei G; Janus E; Scazufca M; Laatikainen T; Jerome CS; Bongard V; Ribeiro R; Erbel R; Gonzalez-Villalpando ME; Galvano F; Jafar T; Soderberg S; Qasrawi RF; Onat A; Zejglicova K; Chen FF; Wanderley RD; Dhimal M; Chirita-Emandi A; Katibeh M; Cuschieri S; Hantunen S; Ferrao T; Assah FK; Musil V; Breckenkamp J; Abarca-Gomez L; Bjerregaard P; Elliott P; Cameron C; Cui LF; Gulliford MC; Eggertsen R; Niiranen TJ; Heshmat R; Christensen K; Widyahening IS; Ma GS; Shiri R; He YN; Gaspoz JM; Stieber J; Nabipour I; Kazakbaeva GM; Kampmann FB; Tjandrarini DH; van der Schouw YT; Wu FC; O'Neill TW; Safi S; Suka M; Bastos JLD; Keramati M; Maniego LV; Nang EEK; Hashemi-Shahri SM; Senbanjo IO; Moreno LA; Gonzalez-Rivas JP; Glavic MM; Bhargava SK; Coppinger TC; Lam TH; El-Khateeb M; Tshepo L; Tai ES; Koziel S; Bruno G; Hange D; Yiallouros PK; Ezzati M; Gurzkowska B; Wang YX; Tullu F; Ferrer E; Dzerve V; Furusawa T; Francis DK; Jonas JB; Wang MD; Pajak A; Bonilla-Vargas A; Romaguera D; Lin HH; Hendriks ME; Cadena LH; Erasmus RT; Sein AA; Porta M; Forsner M; Safarpour AR; Thijs L; Shalnova SA; Keil U; Dzakula A; Chan AW; Wilks RJ; Kalter-Leibovici O; Ye XW; Wang XJ; Rarra V; Tuomilehto J; Lemogoum D; Kurjata P; Regecova V; Azimi-Nezhad M; Ochimana C; Haugsgjerd T; Jelakovic B; Costanzo S; Manios Y; Yang L; Batyrbek A; Madar AA; Hu YH; Bueno-de-Mesquita HB; Le TD; Sans S; Menezes AMB; Saki N; Kalpourtzi N; Schnohr P; Parsaeian M; Ulmer H; Radisauskas R; Muller-Nurasyid M; Capanzana MV; Shanthirani CS; Muiesan ML; Carlsson AC; Marcil A; Vineis P; Villalpando S; Nowak-Szczepanska N; Reina DAR; van Valkengoed IGM; Ibrahim MM; Mohan V; Riboli E; Arlappa N; Schultsz C; Williams EA; Goncalves H; Fouad HM; Huiart L; Le Coroller G; Soares FC; Nejatizadeh A; Mossakowska M; Ahmad NA; Ohara K; Fumihiko M; Deschamps V; Hardman CM; Makdisse M; Tell GS; Robitaille C; Zhao MH; Braeckman L; Theodoridis X; Malyutina SK; Grajda A; Fakhretdinova AA; Khang YH; Pednekar MS; Pradeepa R; Sophiea MK; Azizi F; Qorbani M; Vrkic TZ; Klumbiene J; Aly E; Shamah-Levy T; Kumar RK; Plans-Rubio P; Guan OP; Gudnason V; Solomon B; Santos MP; Strufaldi MW; Mirjalili MR; Kaur P; Mini GK; Sakarya S; Rech CR; Csilla S; Agdeppa IA; Shamshirgaran M; Esmaeili A; Borghs H; Bopp M; Nakamura H; Lunet N; Stein AD; Malhotra R; Graff-Iversen S; Adams RJ; Morejon A; Homayounfar R; Valdivia G; Duante CA; Garcia-de-la-Hera M; Msyamboza KP; Anderssen SA; Crujeiras AB; Boissonnet CP; Lo WC; Molnar D; Majer M; Goldsmith RA; Yoosefi M; Zitt E; Larijani B; Kolle E; Kouda K; Khalili D; Horta BL; Litwin M; Can G; Latt TS; Oliveira IO; Jennings G; Motlagh ME; Gregor RD; Ahmed SH; Knoflach M; Puiu M; Beaglehole R; Chiolero A; Khader YS; Wambiya EOA; Cho B; Rakhimova EM; Giovannelli J; Aounallah-Skhiri H; Lundqvist A; Pham ST; Ritti-Dias RM; Malekzadeh R; Mursu J; Mahasampath G; Xu HQ; Park S; Redon J; Thankappan KR; Hakimi H; George R; Whincup PH; Overvad K; Sorensen TIA; Kromhout D; Macieira LM; Amouyel P; Ong SK; Barros AJD; Osmond C; Romeo EL; Diaz A; Janszky I; Meshram II; Kelishadi R; Wu SL; Khaw KT; Pilav A; Furer A; Herrala S; Matasin M; Ordunez P; Mathur P; Sawada N; Galbarczyk A; Klimek M; Eiben G; Bjorkelund C; Bao TQ; Naidu BM; Sanchez-Abanto J; Levitt NS; Stergiou GS; Michels N; Hill AG; Ruiz-Betancourt BS; Islam M; Htet AS; Brewster LM; Saum KU; Clarke J; Puhakka SE; Kumar RH; Korpelainen R; Boyer CB; Cacciottolo J; Karhus LL; Malekzadeh F; Savva S; Silva DAS; Hata J; Goncalves M; Naderimagham S; Mohammadpourhodki R; Silva CRD; Basit A; Christofaro DG; Fattahi MR; Kheiri B; Cohen E; Zocalo Y; Varghese C; Sebert S; Marrugat J; So HK; Sharafkhah M; Kuulasmaa K; Staessen JA; Frikke-Schmidt R; Pedro JM; Nguyen QV; Nangia VB; Cowell C; Zeng Y; Nenko I; Mota J; Sjostrom M; Si-Ramlee K; Gregg EW; Bikbov MM; Macia E; Dulskiene V; Drygas W; Widhalm K; Meyer HE; Jelakovic A; Gu DF; Gutierrez L; Stronks K; Ahmadi N; Azmin M; Pichardo RN; McNulty BA; Tuomainen TP; Gottrand F; Kruger HS; Stokwiszewski J; Momenan A; Fall CH; Zdrojewski T; Slusarczyk P; Rusakova IA; Syddall HE; Sobngwi E; Concin H; Montano CM; Thorand B; Mohanna S; Bahijri S; Al Nsour M; Stevens GA; Galenkamp H; Tao Y; Kos J; Murphy N; Jaddou HY; Rosengren A; Biasch K; Ruiz-Castell M; Yang XG; Bamoshmoosh M; Holdsworth M; Pizarro AN; Pahomova E; Queiroz D; D'Arrigo G; Mohamed MK; Stocks T; Kontto JP; Mu TT; Krokstad S; Ortiz PJ; Cooper C; Vanderschueren D; Dias-da-Costa JS; Lim WY; Benchekor SM; Hanif AAM; Aghazadeh-Attari J; Ramachandran A; Azevedo A; Hayes AJ; McLean RM; Gonzalez-Chica DA; Russo P; Slowikowska-Hilczer J; Li YP; Tan EJ; Wei WB; Lanska V; Eldemire-Shearer D; Dorr M; Smeeth L; Franco MD; Eghtesad S; Faeh D; Revilla L; Kemper HCG; De Curtis A; Grammatikopoulou MG; Martorell R; Mohammadi Z; Minh HV; Torres-Collado L; Huisman M; Ferrari M; Geleijnse JM; Verschuren WMM; Muhihi AJ; Nagel G; Hobbs M; Miranda JJ; Mann JI; Toft U; Ansong D; Jozwiak J; Lin YT; Moura-dos-Santos MA; Sepanlou SG; De Backer G; Mollehave LT; Chirlaque MD; Mallikharjuna K; Johansson M; Cureau FV; Dragano N; Wang Q; Furdela V; Zakavi SR; McGarvey ST; Iotova V; Peykari N; Mehdipour P; de Paiva KM; Varbo A; Tarawneh MR; Cruz JJ; Topbas M; Sung YT; Wojtyniak B; Lundqvist R; Hormiga CM; Ghimire A; Lopez T; Soumare A; Assuncao MCF; Paciorek CJ; Tamosiunas A; Matlosz P; Dorobantu M; Thomas N; Luksiene D; Rampal L; Tanser F; Lele ECB; Figueiro TH; Neuhauser H; Bueno G; Steene-Johannessen J; Barbagallo CM; Peres KGDA; Ishida T; Amarapurkar DN; Sparrenberger K; Rutkowski M; Lopez-Garcia E; Dickerson TT; Monterrubio-Flores E; Szklo M; Chetrit A; Zhang ZY; Mustafa N; Moghaddam SS; Eddie R; Faramarzi E; Peres MA; Shi ZM; Maira PM; Heier M; Bezerra J; Tham YC; Garnett SP; Kuciene R; Kheradmand M; Censi L; de Oliveira PD; Trichopoulos D; Viet L; Kutsenko V; Carvalho J; Moitry M; Neovius M; Blokstra A; Ferguson TS; Shrestha N; Gureje O; Pigeot I; Taylor A; Gao P; Clays E; Mansour-Ghanaei F; Reganit PFM; Davletov K; Htay TT; Chee ML; Kalmatayeva Z; Jamrozik K; Song Y; Ha S; Benson LS; Lhoste VPF; Willeit J; Poudyal A; Husseini AS; Chadjigeorgiou CA; Koskinen S; Benet M; Park SW; Eslami S; Narake S; Kristensen PL; Laxmaiah A; Bobak M; Isiguzo GC; Pasquet P; Bjertness E; Virtanen JK; Barkat A; Iannone AG; Gruden G; Gialluisi A; Sadjadi A; Moreira LB; Veronesi G; Savin S; Radic I; McLean SB; Ghasemi E; Ho SC; Nieto-Martinez RE; Chen CJ; Theobald H; Killewo J; Mereke A; El Ati J; Kujala UM; Dekkaki IC; Omar MA; Moosazadeh M; Salvetti M; Riley LM; Kowlessur S; Ho SY; Duda RB; Aris T; Ahrens W; Namesna J; Claessens F; Fuchs FD; Ikeda N; Zhao D; Sofat R; Ohtsuka R; Houti L; Vollenweider P; Abu-Rmeileh NM; Iacoviello L; Shayesteh AA; Wong NI; Garcia P; Andersen LB; Palli D; Brajkovich I; Zhang LX; Ugel E; Doua K; Aspelund T; Sardinha LB; Mehlig K; Yang Y; DeGennaro V; Nguyen CT; Loit HM; Eliasen M; Vlasoff T; Santos R; Tello T; Jorgensen T; Moschonis G; Gehring U; Schottker B; Rahimikazerooni S; Roggenbuck U; Traissac P; Pan WH; Rodriguez-Artalejo F; Kersting M; Woodward M; Ueda P; Eriksen L; Mbanya JCN; Trinh OTH; Pereira AC; Karaglani E; Zainuddin AA; Menon GR; Kerimkulova A; Sarrafzadegan N; Tynelius P; Monyeki KDK; Ali MM; Kajantie EO; Lind L; Felix-Redondo FJ; Wade AN; Sibai AM; Kafatos A; Gao JL; Nikitin YP; Kusuma YS; Suriyawongpaisal P; Tebar WR; Milkowska K; Khosravi A; Zhou B; Aguilar-Salinas CA; d'Orsi E; Gheorghe-Fronea OF; Somi MH; Misigoj-Durakovic M; Fawwad A; Ono LM; Voutilainen A; Mavrogianni C; Kulaga Z; Capuano E

Background: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its ...

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Winsvold BS; Sigurdardottir GR; Kahonen M; Ran C; Kurth T; Farkkila M; Belin AC; Gormley P; Sveinsson OA; Ripatti S; Hrafnsdottir MG; Magnusson SH; Widen E; Aromaa A; van Dijk KW; Rosendaal FR; Ullum H; Buring JE; de Boer I; Skogholt AH; Ikram MA; Banasik K; Hautakangas H; Hottenga JJ; Nyholt DR; Noordam R; Dichgans M; Thomas LF; Wessman M; Chalmer MA; van den Maagdenberg AMJM; Freilinger T; Olesen J; Kallela M; Thorgeirsson TE; Bjornsdottir A; Hveem K; Kogelman LJA; Zwart JA; Penninx BWJH; Raitakari OT; Stefansson K; Hansen TF; Burgdorf KS; Hagen K; Garbrielsen ME; Benner C; Johnsen MB; Pedersen OB; Harder AVE; Lighart L; Malik R; Ruotsalainen SE; Ghanbari M; Vijfhuizen LS; Kristoffersen ES; Lehtimaki T; Pelzer N; Ridker PM; Happola P; Jarvelin MR; Pirinen M; Chasman DI; Bjornsdottir G; Brumpton B; Terwindt GM; Boomsma DI; Erikstrup C; Stefansson H; Artto V; Palotie A

Genome-wide association analyses identify 123 susceptibility loci for migraine and implicate neurovascular mechanisms in its pathophysiology. Subtype analyses highlight risk loci specific for migraine with or without aura ...

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Zemel BS; Iniguez C; Pedersen O; Koletzko B; Escribano J; Monnereau C; Uitterlinden AG; Bisgaard H; Atalay M; Froguel P; Curtin JA; Chesi A; Sly PD; Zeggini E; Heude B; Geller F; Freathy RM; Pennell CE; Horikoshi M; Viikari J; Grote V; Yengo L; Lyytikainen LP; Kuhnapfel A; Korner A; Holm JC; Hakonarson H; Verduci E; Gruszfeld D; Reischl E; Teo KK; Lehtimaki T; Bilbao JR; Bacelis J; Rivadeneira F; Beaumont RN; Reijneveld SA; Johansson S; Vonk JM; Lakka TA; Jarvelin MR; Morgen CS; Timpson NJ; Schnurr TM; Plomin R; Kirsten H; Eriksson JG; Ahluwalia TS; Thiering E; Pahkala K; van der Most PJ; Felix JF; Grarup N; Farooqi IS; Standl M; Simpson A; Groen-Blokhuis M; Bustamante M; Hattersley AT; Barroso I; Njolstad PR; Medina-Gomez C; Sebert S; Charles MA; Hottenga JJ; Lindi V; Raitakari O; Melbye M; Brown CD; Stergiakouli E; Vrijheid M; van Beijsterveldt CEM; Bradfield JP; Boomsma DI; Sunyer J; Zafarmand MH; Vilor-Tejedor N; Hypponen E; Scholz M; Vogel M; Jaddoe VWV; Holt PG; Heinrich J; Landgraf K; Closa-Monasterolo R; Custovic A; Dedoussis GD; Li AHL; Rzehak P; Hansen T; Helgeland O; Lind MV; Vaudel M; Cousminer DL; Snieder H; Alyass A; Joro R; Vrijkotte TGM; Grant SFA; Ntalla I; van Schaik BDC; Meyre D; Lowry E; Michaelsen KF; Hollensted M; Have CT; Stokholm J; Smith GD; Heiskala A; Koppelman GH; Selzam S; Kiess W; McCarthy MI; Knight BA; Beilin LJ; Nohr EA; Jacobsson B; Wheeler E; Panoutsopoulou K; Clement K; Nielsen TRH; Carstensen L; Feenstra B; Niinikoski H; Karhunen V; Sorensen TIA; Frithioff-Bojsoe C; Wang CRA; Chawes B; Bonnelykke K; Kahonen M; Torrent M; Langhendries JP; Vogelezang S; Fedko IO; Leinonen JT; Vinding RK; Power C; Ong K; Mori TA; Widen E; Murray C; Santa-Marina L; Pitkanen N; Oldehinkel AJ

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

The relationship between temperament, polygenic score for intelligence and cognition: A population-based study of middle-aged adults

Dobewall H; Taittonen L; Jokinen E; Lehtimaki T; Cloninger CR; Raitakari O; Tolli P; Ravaja N; Pahkala K; Hutri-Kahonen N; Ahola-Olli A; Rovio S; Tossavainen P; Keltikangas-Jarvinen L; Laitinen TT; Saarinen A; Hintsanen M; Kahonen M

We investigated whether temperament modifies an association between polygenic intelligence potential and cognitive test performance in midlife. The participants (n = 1647, born between 1962 and 1977) were derived from the ...

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Yang Q; Felix JF; O'Connell J; Sveinbjornsson G; Schulz CA; Lieb W; Guilianini F; Ghasemi S; Wilson JF; Preuss MH; Palmer ND; Willer CJ; Hartman CA; Kramer BK; Foo VHX; Bansal N; Hung AM; Thorsteinsdottir U; Parsa A; Yu Z; Pirastu N; Gordon SD; Verweij N; Porteous DJ; Rice KM; Stefansson K; Magnusson PKE; Kuusisto J; Hveem K; Chai JF; Stringham HM; Waeber G; Campbell A; Phillips LS; Tin A; Heng CK; Franke A; Spedicati B; Gunther F; Huang W; Christensen K; Mishra PP; Langefeld CD; Morris AP; Okada Y; Burkhardt R; Ning B; Ciullo M; Schottker B; Schmidt R; Tao R; Pontali G; Ehret G; Friedlander Y; Nikus K; Girotto G; Tayo B; Giedraitis V; Stanzick KJ; Jakobsdottir J; Holm H; Gao H; Oldehinkel AJ; Vanderwerff BR; Orho-Melander M; Mychaleckyj JC; Kronenberg F; Loos RJF; Wallentin L; Citterio L; Lucae S; Rasheed H; Wang CL; Vaccargiu S; Bottinger EP; Salomaa V; Kahonen M; Scholz M; Waldenberger M; Bochud M; Freitag-Wolf S; Morgan A; Milaneschi Y; Tham YC; Kooner JS; O'Donoghue ML; Haller T; Stark KJ; Kovacs P; Daw EW; Korner A; Kerr SM; Salvi E; Sedaghat S; Melander O; Miliku K; Zonderman AB; Svensson PO; Polasek O; Kammerer CM; Rabelink TJ; Rudan I; Marz W; Rivadeneira F; Kastarinen M; Teumer A; Kramer H; Gaziano JM; de Vries APJ; Tan NYQ; Lim SC; Kirsten H; Feresin A; Noordam R; Thio CHL; Rossing P; Spracklen CN; Cook JP; Montgomery GW; Brumpton B; Gasparini P; Magi R; Patil SB; Lanzani C; Raitakari OT; Hamet P; Metspalu A; Smith AV; Waterworth DM; Manunta P; Reilly DF; Jung B; Martins J; Rizzi F; Nolte IM; Rowan BX; Vogelezang S; Graham SE; Heid IM; Pramstaller PP; Jaddoe VWV; Penninx BWJH; Gorski M; Coresh J; Feitosa MF; Koenig W; Boehnke M; Kuokkanen M; Banas B; Marten J; Rotter JI; Ikram MA; Lehtimaki T; Lyytikainen LP; Strauch K; Boutin TS; Gudbjartsson DF; Campbell H; Sim RZH; Wang YX; Tremblay J; Podgornaia AI; Catamo E; Lee JJM; Vitart V; Nalls MA; Xu J; Pistis G; Volker U; Peters A; Shaffer CM; Arnlov J; Delgado GE; Ryan KA; Mook-Kanamori DO; Rueedi R; Correa A; Divers J; van der Most PJ; Cocca M; Tai ES; Bergmann S; Martin NG; Hallan S; Launer LJ; Josyula NS; Lukas MA; Mononen N; Horn K; van der Harst P; Stumvoll M; Perola M; Chambers JC; Carroll RJ; Francescatto M; Raffield LM; Hayward C; Chee ML; Khor CC; Ahluwalia TS; Gansevoort RT; Snieder H; Brenner H; Biggs ML; Halbritter J; Hwang SJ; Padmanabhan S; Tonjes A; Chu AY; Cheng CY; Pattaro C; Thomas LF; Klaric L; Endlich K; Nutile T; Meitinger T; Taylor KD; De Grandi A; Laakso M; White HD; Bakker SJL; Kottgen A; Eckardt KU; Yerges-Armstrong LM; Sieber KB; Wei WB; Schmidt H; La Bianca M; Kanai M; Yasuda M; Ising M; Dehghan A; Kavousi M; Hutri-Kahonen N; Lindgren CM; Loeffler M; Hoppmann A; Dittrich K; Wuttke M; Jonas JB; Gieger C; Rosenkranz AR; Matsuda K; Guo F; Winkler TW; Mascalzoni D; Mahajan A; Kamatani Y; Dorajoo R; Gao X; Boerwinkle E; Joshi PK; Sabanayagam C; Evans MK; Psaty BM; Cusi D; Hofer E; Ruggiero D; Li Y; Sim XL; Boger CA; Toniolo D; Freedman BI; Piratsu M; Smith BH; Concas MP; Nadkarni GN; Robinson-Cohen C; Hicks AA; Felicita SC; Mohlke KL; Elliott P; Bergler T; Kleber ME; Gudnason V; Biino G; Liu JJ; Fuchsberger C; Esko T; Zhang WH; Kubo M; Asvold BO; Schupf N; Vollenweider P; Thiery J; Wong TY; van Dam RM; Ponte B; Ghanbari M; Wojczynski MK; Li HT; Whitfield JB; Ridker PM; Tzoulaki I; Teren A; Nauck M; Li M; Ho K; Lind L; Kiess W; de Borst MH; Akiyama M; Gogele M; Olafsson I; Chasman DI; Corre T; Province MA; Sulem P; Czamara D; Lange LA; de Mutsert R; Pendergrass SA; Devuyst O

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.Reduced glomerular filtration rate (GFR) can progress to ...

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study

Raitoharju E; Lehtimaki T; Mishra BH; Holm L; Marttila S; Kahonen M; Toronen P; Mononen N; Hanninen I; Mishra PP; Hurme M; Raitakari O

Smoking as a major risk factor for morbidity affects numerous regulatory systems of the human body including DNA methylation. Most of the previous studies with genome-wide methylation data are based on conventional association ...

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Brenner H; Kasela S; Sotoodehnia N; Smith AK; Relton C; Doerr M; Wielscher M; Robinson O; Psaty BM; Baccarelli AA; Selvin E; Deloukas P; van Meurs JBJ; Marouli E; Mustafa R; Ghanbari M; Bell JT; Kahonen M; Krogh V; Teumer A; Levy D; Waldenberger M; Chambers JC; Brody JA; van der Harst P; Panico S; Colicino E; Hurme MA; Bis JC; Peters A; Guan WH; Karhunen V; Chen W; Kottgen A; Torres MA; Matullo G; Cardona A; Lehne B; Bodinier B; Nauck M; Tumino R; Fiorito G; Dehghan A; Verweij N; Schlosser P; Iacoviello L; Marioni RE; Kuehnel B; Graf-Schindler J; Kooner JS; Beekman M; Fisher K; Koenig W; Chadeau-Hyam M; Milani L; Tzala E; Vineis P; Waite LL; Lehtimaki T; Jarvelin MR; Conneely KN; Farlik M; Heijmans BT; Palaniswamy S; Deary IJ; Mandaviya PR; Rathmann W; Miller AH; Gao X; Herzig KH; Ong KK; Elliott P; Walton E; Cugliari G; Joehanes R; Zhang Y; Raitakari OT; Boerwinkle E; Wilson R; Loh M; Xia YJ; Grabe HJ; Tsai PC; Li SX; Mishra PP; Weninger W; Zhang T; Tanaka T; Sacerdote C

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive ...

A saturated map of common genetic variants associated with human height

Abecasis GR; Adair LS; Adams HHH; Aguilar-Salinas CA; Ahluwalia TS; Akiyama M; Al-Mulla F; Allison MA; Alvarez M; Andersen MK; Ani A; Appadurai V; Arbeeva L; Arias JD; Arnett DK; Asselbergs FW; Assimes TL; Asvold BO; Attia J; Auton A; Banas B; Bandinelli S; Bartell E; Bennett DA; Bergler T; Berndt SI; Bharadwaj D; Bhaskar S; Bielak LF; Biino G; Bisgaard H; Boehnke M; Boerwinkle E; Boger CA; Bollepalli S; Bonnelykke K; Bonnycastle LL; Boomsma DI; Borglum AD; Borja JB; Bork-Jensen J; Bouchard C; Bowden DW; Bradfield JP; Bradford Y; Brandslund I; Braund PS; Brody JA; Brumpton B; Burgdorf KS; Buring JE; Cade BE; Cai H; Cai QY; Campbell A; Canadas-Garre M; Catamo E; Caulfield MJ; Chai JF; Chai XR; Chambers JC; Chandak GR; Chang LC; Chang YC; Chanock SJ; Chasman DI; Chaturvedi N; Chen CH; Chen SH; Chen YDI; Chen ZM; Cheng CY; Chesi A; Cho YS; Choi SH; Christofidou P; Christophersen IE; Chung RH; Ciullo M; Cocca M; Cole JW; Collins FS; Concas MP; Cooper RS; Couture C; Cruz M; Cucca F; Cuellar-Partida G; Cupples LA; Cutler MJ; Damrauer SM; Danning R; Dantoft TM; Daw EW; De Jager PL; Dedoussis GV; Degenhard F; Delgado GE; Delitala A; Deloukas P; Demirkan A; Deng X; Devineni P; Dietl A; Dimitriou M; Dimitrov L; Dorajoo R; Du SF; Easton DF; Ekici AB; Elders PJM; Eliasen AU; Eliassen AH; Ellinor PT; Elmstahl S; Engmann JE; Erdmann J; Esko T; Evans MK; Fairhurst-Hunter Z; Farmaki AE; Fatkin D; Faul JD; Feenstra B; Feitosa MF; Fernandez-Lopez JC; Ferreira T; Ferrucci L; Ford I; Forer L; Fornage M; Francescatto M; Franke A; Franks PW; Frayling TM; Freedman BI; Freitag-Wolf S; Fuchsberger C; Galesloot TE; Gao Y; Gao ZS; Gasparini P; Geller F; Giannakopoulou O; Gieger C; Girotto G; Giulianini F; Gjesing AP; Goddard ME; Goel A; Golightly YM; Gonzalez-Villalpando C; Gordon SD; Gordon-Larsen P; Gorski M; Graff M; Graham SE; Grallert H; Grant SFA; Grarup N; Griffiths L; Grove J; Gudnason V; Guo XQ; Gustafsson S; Haessler J; Haiman C; Hakonarson H; Hansen T; Hansen TF; Hart LMT; Hartman CA; Hattersley AT; Havulinna AS; Haworth SJ; Hayward C; He J; Heard-Costa N; Hebbar P; Heckbert SR; Heid IM; Heng CK; Hengstenberg C; Hewitt AW; Highland HH; Hindy G; Hirschhorn JN; Hishigaki H; Ho YLA; Hofer E; Holliday E; Horn K; Hornsby WE; Hottenga JJ; Hoyng CB; Huang HY; Huang J; Huang PL; Huang W; Huerta-Chagoya A; Huffman JE; Hung YJ; Hunt SC; Huo SF; Hveem K; Hwang MY; Hypponen E; Iacono WG; Ichihara S; Iha H; Ikeda DD; Ikram MA; Isasi CR; Isono M; Jackson AU; Jackson RD; Jager S; Jansen IE; Jarvelin MR; Ji YJ; Jiang YX; Jin ZB; Jockel KH; Johansson I; Jonas JB; Jonsson A; Jorgensen T; Joshi PK; Jousilahti P; Jukema JW; Justice AE; Kahonen M; Kalafati IP; Kamatani Y; Kanai M; Kang KD; Kanoni S; Kaprio J; Karaderi T; Kardia SLR; Karhus LL; Karpe F; Kasturiratne A; Kato N; Katsuya T; Kawaguchi T; Kee F; Kember RL; Kentistou KA; Kessler T; Khera AV; Khor CC; Kiemeney LALM; Kim BJ; Kim EK; Kim HL; Kim HN; Kim YJ; Kirchhof P; Kivimaki M; Kleber ME; Knol MJ; Koh WP; Koistinen HA; Kolovou GD; Kooner JS; Kooperberg C; Kottgen A; Kovacs P; Kraaijeveld A; Kraft P; Krauss RM; Kumari M; Kurbasic A; Kutalik Z; Laakso M; Lange LA; Langenberg C; Launer LJ; Lauzon M; Le Marchand L; Le P; Lea R; Lee H; Lee JY; Lee NR; Lehtimaki T; Leonard HL; Lettre G; Li HX; Li LM; Li SCA; Li XH; Li XY; Liang JJ; Lieb W; Lin HH; Lin K; Lin SY; Lin X; Lind L; Lindgren CM; Linneberg A; Liu CT; Liu J; Liu JJ; Liu XP; Lo KS; Locke AE; Loeffler M; Loh PR; London B; Long JR; Loos RJF; Lores-Motta L; Luan JA; Lubitz SA; Lull K; Lye SJ; Lyssenko V; Lyytikainen LP; Machado M; Mackey DA; Magi R; Magnusson PKE; Mahajan A; Malden DE; Mamakou V; Mangino M; Manichaikul A; Marcus GM; Marouli E; Marten J; Martin NG; Marz W; Matsuda F; Mattheisen M; Mavarani L; McCarthy MI; McDaid AF; McGarrah RW; McGue M; McKnight AJ; Medina-Gomez C; Medland SE; Meidtner K; Melendez TL; Mellstrom D; Mercader JM; Metspalu A; Miao JK; Milaneschi Y; Miller JE; Millwood IY; Mishra PP; Mitchell BD; Mitchell P; Mitchell RE; Mohlke KL; Mollehave LT; Mook-Kanamori DO; Moore A; Morgan A; Morris AD; Mucci LA; Mucha S; Mukamel RE; Munroe PB; Munz M; Nakatochi M; Nalls MA; Nazarian S; Nelson AE; Nelson CP; Nethander M; Neville MJ; Newton-Cheh C; Ng MCY; Nho CW; Nielsen AA; Nielsen CS; Nolte IM; Nongmaithem SS; Noordam R; North KE; Nothen MM; Ntalla I; Nutile T; O'Donnell CJ; Ohlsson C; Okada Y; Oldehinkel AJ; Orozco L; Pahkala K; Pajukanta P; Palmer CNA; Pandit A; Parna K; Parra EJ; Pattaro C; Pauper M; Pedersen O; Pennell CE; Penninx BWJH; Perusse L; Peters A; Petersen ERB; Petersen LV; Peyser PA; Pitkanen N; Polasek O; Porteous DJ; Posthuma D; Poveda A; Power C; Pramstaller PP; Preuss MH; Province MA; Pyarajan S; Qi QB; Qu J; Rader DJ; Raffield LM; Raghavan S; Raitakari OT; Rakugi H; Ralhan S; Rallidis LS; Ramirez J; Rao DC; Rasheed A; Raven D; Rayner NW; Redline S; Reilly DF; Reiner AP; Rhee SY; Ridker PM; Rienstra M; Ripatti S; Ritchie MD; Rivadeneira F; Riveros C; Roden DM; Rohde R; Rosendaal FR; Rotter JI; Rudan I; Rueger S; Ruggiero D; Ruotsalainen SE; Rutters F; Ryan KA; Sabanayagam C; Sabater-Lleal M; Sakaue S; Saleheen D; Salomaa V; Samani NJ; Sanghera DK; Sattar N; Saxena R; Schmidt B; Schmidt H; Schmidt R; Scholz M; Schulze MB; Schunkert H; Scott LJ; Scott RJ; Sendamarai A; Sever P; Shen BT; Shi JCZ; Shin JH; Shiroma EJ; Shoemaker MB; Shu XO; Sidore C; Sidorenko J; Sim X; Simonsick EM; Sims M; Singh JR; Singleton AB; Sinner MF; Sitlani CM; Slieker RKC; Smit RAJ; Smith AV; Smith JA; Smith JG; Smyth LJ; Snieder H; Southam LE; Spector TD; Spracklen CN; Stampfer MJ; Stark KJ; Stefansson K; Steinthorsdottir V; Strachan DP; Sun L; Sun YV; Tabara Y; Tai ES; Takeuchi F; Tallapragada D; Tang H; Tardif JC; Taylor KD; Tayo BO; Tcheandjieu C; Terzikhan N; Tesolin P; Teumer A; Thanaraj TA; Theusch E; Thompson DJ; Thorleifsson G; Thorsteinsdottir U; Timmers PRHJ; Timpson NJ; Tonjes A; Tremblay A; Trompet S; Tuomi T; Tuomilehto J; Turman C; Tusie-Luna MT; Uitterlinden AG; Vaccargiu S; Van der Velde N; Vedantam S; Verma SS; Verweij N; Veturi Y; Vidal PM; Visscher PM; Vitart V; Volker U; Vollenweider P; Volzke H; Vrieze S; Wacher-Rodarte NH; Walker M; Walters RG; Wang CA; Wang CL; Wang LH; Wang YX; Wang Z; Wareham NJ; Warren HR; Watanabe RM; Watkins H; Wei WB; Weir DR; Werge TM; Wickremasinghe AR; Widen E; Wielscher M; Wiggins KL; Wilkens LR; Willemsen G; Willer CJ; Willett WC; Wilson JF; Winkler TW; Winsvold BS; Wong A; Wong TY; Woo JT; Wood AR; Wright AF; Wu JY; Wu Y; Wuttke M; Xia R; Xie T; Xu HC; Yajnik CS; Yamamoto K; Yang J; Yang JY; Yao J; Yengo L; Yin XY; Yokota M; Young H; Young KL; Yousri NA; Yu L; Yuan JM; Zeggini E; Zemel BS; Zeng LY; Zhang WH; Zhang XY; Zhao JH; Zhao W; Zheng W; Zhou W; Zhu XF; Zimmermann ME; Zmuda JM; Zoledziewska M; Zonderman AB; Zwart JA; de Borst GJ; de Groot LCPGM; de Kleijn DPV; de Silva HJ; den Hollander AI; van Dam RM; van Duijn CM; van Klinken JB; van Schoor NM; van Setten J; van der Harst P; van der Laan SW; van der Most PJ

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). ...

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Ahluwalia TS; Ameur A; Balkhiyarova Z; Balslev-Harder MN; Bandinelli S; Bartz TM; Baumeister SE; Beilby J; Bentley AR; Berry D; Bielak LF; Bis JC; Blangero J; Boehnke M; Boomsma DI; Bouchard C; Brage S; Braund PS; Brody JA; Broos S; Bruinenberg M; Chasman DI; Chong M; Chu AY; Cole JW; Collins FS; Cornelis MC; Cupples LA; De Geus EJC; Deldicque L; Den Hoed M; Dorajoo R; Dorr M; Dueker ND; Ekelund U; Emmerich A; Enroth S; Esko T; Evans MK; Faul JD; Feenstra B; Feitosa MF; Fernandez-Rhodes L; Ferrucci L; Fohner AE; Fornage M; Fox C; Franco OH; Galesloot TE; Garland T; Gieger C; Gordon SD; Graff M; Grarup N; Gudnason V; Gyllensten U; Hall LM; Haller T; Hansen T; Hartman CA; Hartwig FP; Hayward C; Heard-Costa N; Heiss G; Hemerich D; Hevener AL; Hillis DA; Holzapfel C; Horta BL; Hui J; Huikari V; Hypponen E; Illig T; Jackson AU; Jago R; James A; Jarvelin MR; Johansson A; Johnson WC; Jorgensen AM; Joshi PK; Jung T; Kaakinen MA; Kahonen M; Kardia SLR; Karlsson R; Kasbohm E; Kerr KF; Kiemeney LA; Kilpelainen TO; Kim B; Koh WP; Kolcic I; Koolhaas CM; Kraft PP; Krook A; Kutalik Z; Kuusisto J; Laakso M; Lagou V; Langenberg C; Launer LJ; Le Marchand L; Lehtimaki T; Li AH; Lind PA; Linneberg A; Liu CT; Loos RJF; Lorentzon M; Luan JA; Lyytikainen LP; Magnusson PKE; Mangino M; Martin NG; Mazzaferro E; Medland SE; Melbye M; Metspalu A; Metzendorf C; Meyre D; Milaneschi Y; Monroe KR; Moore T; Moscati A; Musk B; Nelson CP; Nolte IM; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pacolet A; Pare G; Park T; Pedersen NL; Pedersen O; Penninx BWJH; Pers TH; Perusse L; Peters A; Peyser PA; Pillon NJ; Polasek O; Pool R; Power C; Prokopenko I; Raitakari OT; Reedik M; Reiner AP; Richmond RC; Ridker PM; Rivera NV; Robiou-Du-Pont S; Rotimi CN; Rudan I; Ryan K; Samani NJ; Sarzynski MA; Schraut KE; Schulz CA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Sim X; Smith AV; Smith GD; Smith JA; Snieder H; Sonestedt E; Sorensen TIA; Spector TD; Stringham HM; Strom M; Tai ES; Tanaka T; Teo KK; Teumer A; Thomis MAI; Thorand B; Timpson NJ; Tonjes A; Tremblay A; Turman C; Uitterlinden AG; Van Dam RM; Van Duijn CM; Van Rooij FJA; Van Schoor N; Van Vliet-Ostaptchouk JV; Van der Most PJ; Van der Velde N; Vangipurapu J; Vanmunster M; Vidal PM; Volker U; Vollenweider P; Volzke H; Voortman T; Waeber G; Wang Z; Wareham NJ; Weir DR; Wichmann HE; Willemsen G; Williams K; Wilson JF; Wong Q; Xu HC; Young KL; Yuan JM; Zhang XS; Zhao JH; Zhao W; Zierath JR; Zillikens MC; Zonderman AB

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry ...