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Feasibility of FreeSurfer Processing for T1-Weighted Brain Images of 5-Year-Olds: Semiautomated Protocol of FinnBrain Neuroimaging Lab
<p>Pediatric neuroimaging is a quickly developing field that still faces important methodological challenges. Pediatric images usually have more motion artifact than adult images. The artifact can cause visible errors in ...
Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts
<p>High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. ...
Infant and Child MRI: A Review of Scanning Procedures
Magnetic resonance imaging (MRI) is a safe method to examine human brain. However, a typical MR scan is very sensitive to motion, and it requires the subject to lie still during the acquisition, which is a major challenge ...
Infant Sex Moderates the Effects of Maternal Pre- and Postnatal Stress on Executive Functioning at 8 Months of Age
<p>Previous studies report that early life stress, including maternal pre- and postnatal stress, has adverse effects on cognitive development and that these associations might be sex-specific. However, no studies exist on ...
Maternal Anxiety Symptoms and Self-Regulation Capacity Are Associated With the Unpredictability of Maternal Sensory Signals in Caregiving Behavior
The unpredictability of maternal sensory signals in caregiving behavior has been recently found to be linked with infant neurodevelopment. The research area is new, and very little is yet known, how maternal anxiety and ...
Neonatal Amygdala Volumes and the Development of Self-Regulation from Early Infancy to Toddlerhood
<p><i>Objective:</i> At the broadest level, self-regulation refers to a
range of separate, but inter-related, processes (e.g., working memory,
inhibition, emotion regulation) central for the regulation of cognition,
emotion ...
Sleep during infancy, inhibitory control and working memory in toddlers: findings from the FinnBrain cohort study
<div><h3>Background</h3><p>Sleep difficulties are associated with impaired executive functions (EFs) in school-aged children. However, much less is known about how sleep during infancy relates to EF in infants and toddlers. The aim of this study was to investigate whether parent-reported sleep patterns at 6 and 12 months were associated with their inhibitory control (IC) and working memory (WM) performances at 30 months.</p><h3>Methods</h3><p>This study included children whose parents filled in a sleep questionnaire at 6 or 12 months and who participated in the development assessment at 30 months (initial available sample at 30 months; N = 472). The final sample comprised (a) 359 infants with IC task and sleep questionnaire at 6 months and 322 toddlers at 12 months and (b) 364 infants with WM task and sleep questionnaire at 6 months and 327 toddlers at 12 months. Nighttime, daytime and total sleep duration, frequency of night awakenings, time awake at night, and proportion of daytime sleep were assessed at 6 and 12 months using the Brief Infant Sleep Questionnaire. IC at 30 months was measured using a modified version of the Snack Delay task, and WM was measured at 30 months using the Spin the Pots task. Further, children were divided into three groups (i.e., “poor sleepers”, “intermediate sleepers”, and “good sleepers”) based on percentile cut-offs (i.e., <10th, 10th–90th and > 90th percentiles) to obtain a comprehensive understanding of the direction and nature of the associations between sleep and EF in early childhood.</p><h3>Results</h3><p>Our results showed an inverted U-shaped association between proportion of daytime sleep at 12 months and IC at 30 months, indicating that average proportions of daytime sleep were longitudinally associated with better IC performance. Furthermore, a linear relation between time awake at night at 12 months and WM at 30 months was found, with more time awake at night associating with worse WM.</p><h3>Conclusions</h3><p>Our findings support the hypothesis that sleep disruption in early childhood is associated with the development of later EF and suggest that various sleep difficulties at 12 months distinctively affect WM and IC in toddlers, possibly in a nonlinear manner.<br></p></div>...
The role of alexithymia and perceived stress in mental health responses to COVID-19: A conditional process model
<p><strong>Background</strong><br>Little is known about the psychological mechanisms underlying the mental health problems related to the COVID-19 pandemic. Hypothetically, perceived stress and alexithymia may be factors ...
Human milk cortisol concentration predicts experimentally induced infant fear reactivity: moderation by infant sex
<p>Little consideration has been given to the possibility of human infant development being shaped via lactocrine programming, and by breast milk cortisol levels specifically. Despite animal models indicating that ...
Infant fecal microbiota composition and attention to emotional faces
The gut microbiota has been suggested to influence neurodevelopment in
rodents. Preliminary human studies have associated fecal microbiota
composition with features of emotional and cognitive development as well
as differences in thalamus-amygdala connectivity. Currently,
microbiota-gut-brain axis studies cover heterogenous set of infant and
child brain developmental phenotypes, while microbiota associations with
more fine-grained aspects of brain development remain largely unknown.
Here (N = 122, 53% boys), we investigated the associations
between infant fecal microbiota composition and infant attention to
emotional faces, as bias for faces is strong in infancy and deviations
in early processing of emotional facial expressions may influence the
trajectories of social-emotional development. The fecal microbiota
composition was assessed at 2.5 months of age and analyzed with 16S rRNA
gene sequencing. Attention to emotional faces was assessed with an
age-appropriate face-distractor paradigm, using neutral, happy, fearful,
and scrambled faces and salient distractors, at 8 months of age. We
observed an association between a lower abundance of Bifidobacterium and a higher abundance of Clostridium
with an increased “fear bias,” that is, attention toward fearful versus
happy/neutral faces. This data suggests an association between early
microbiota and later fear bias, a well-established infant phenotype of
emotionally directed attention. However, the clinical significance or
causality of our findings remains to be assessed....