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Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma
<p><strong>Objectives: </strong>Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects and thus is ...
Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer
<p>Purpose: To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of F-18-1-amino-3-fluorocyclobutane-1-carboxylic ...
Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
<p>Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor
important in diverse biological processes including cell proliferation
and survival. Upregulation of EGFR activity due to over-expression or ...
Uusia työkaluja paikallisesti edenneen ja etäpesäkkeisen eturauhassyövän lääkehoitoon
<p>Eturauhassyöpä on miehillä tavallisimmin todettu syöpä ja miesten toiseksi yleisin syöpäkuolemien aiheuttaja Suomessa. Levinneen eturauhassyövän lääkehoidossa keskeistä on androgeenireseptorin toiminnan estäminen ...
Gadolinium retention in gliomas and adjacent normal brain tissue: association with tumor contrast enhancement and linear/macrocyclic agents
<p>Purpose: To quantitate gadolinium deposits in gliomas and adjacent normal brain specimens, and to evaluate their association with tumor contrast enhancement and the type of gadolinium-based contrast agent (GBCA) ...
Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort
<p><strong>Introduction</strong> <br></p><p>Prognostic biomarkers and novel therapeutic approaches have been slow to emerge in the treatment of head and neck squamous cell carcinoma (HNSCC). In this study, an HNSCC patient ...
A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma
After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...