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Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the
most common metastatic skin cancer, and its incidence is increasing
globally. Long noncoding RNAs (lncRNA) are involved in various
biological ...
EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer
<p>Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favorable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited and ...
Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics
<p>Gastric cancer is traditionally divided into intestinal and diffuse
histological subtypes, but recent molecular analyses have led to novel
classification proposals based on genomic alterations. While the
intestinal- ...
Tumour-cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma
<p><strong>Background</strong> The incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide. </p><p><strong>Objectives</strong> To study the role of the complement classical ...
The Mutational Profile of Unicystic Ameloblastoma
BRAF V600E is the most common mutation in conventional ameloblastoma (AM) of the mandible. In contrast, maxillary AMs appear to harbor more frequently RAS, FGFR2, or SMO mutations. Unicystic ameloblastoma (UAM) is considered ...
Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity
<p>atty acids (FA) are important substrates for brown adipose tissue (BAT)
metabolism, however, it remains unclear whether there exists a
difference in FA metabolism of BAT between lean and obese healthy
humans. In ...